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Gene Review

STAM  -  signal transducing adaptor molecule (SH3...

Homo sapiens

Synonyms: STAM-1, STAM1, Signal transducing adapter molecule 1
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Disease relevance of STAM

  • The remarkable in vivo safety and potency of STAMP warrants the further development of this promising new antiretroviral agent for possible clinical use in patients harboring NRTI-resistant HIV-1 [1].
  • Notably, daily administration of STAMP intraperitoneally or orally for up to 8 consecutive weeks was not associated with any detectable toxicity at cumulative dose levels as high as 6.4 g/kg [1].
  • We report the antiretroviral activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine [STAMP]), a novel aryl phosphate derivative of stavudine, against primary clinical human immunodeficiency virus type 1 (HIV-1) isolates [2].
  • Compared to novispirin G10, the STAMP had an enhanced ability to kill Pseudomonas mendocina [3].
  • Long-term food stamp program participation is differentially related to overweight in young girls and boys [4].

Psychiatry related information on STAM

  • A collector is a person who collects things on purpose, either as a hobby or business, or for personal satisfaction, e.g., stamp, coin, or art collector [5].
  • Organizational effects take place during a critical period in fetal life and put a permanent stamp on the developing brain [6].
  • Use of the vital sign stamp as a systematic screening tool to promote smoking cessation [7].
  • The presence of components of immunoglobulins (Ishii et al. 1975) and complements (Eikelenboom and Stam 1982) in senile plaques suggests that the immunologic mechanisms are involved in the causation of pathologic processes in the brain of patients with Alzheimer's disease [8].
  • Each physician initially responded to questions on their knowledge of the CPGs, and was then randomly assigned to one of four groups that received information about the CPGs while implementing an intervention (the stamp tool) aimed at supporting their decision-making process at the point of care [9].

High impact information on STAM

  • The VHS (Vps27p, Hrs and STAM) domains of the GGA proteins are responsible for the highly specific recognition of these acidic-cluster-dileucine signals [10].
  • A poly(dimethylsiloxane) stamp, patterned in bas-relief and supporting an 80-nanometer-thick gold film, is brought into contact with an 80-nanometer-thick film of poly(methylmethacrylate) supported on n-doped silicon [11].
  • UBPY function is essential for effective downregulation but is likely to be multifaceted, encompassing activity against both K63-linked and K48-linked polyubiquitin chains and including regulation of the stability of ESCRT-associated proteins such as STAM, by reversing their ubiquitination [12].
  • In this report, we demonstrate the functional significance of STAM in cytokine-mediated signal transduction [13].
  • These results strongly implicate STAM in the signaling pathways for cell growth and c-myc induction immediately downstream of the Jaks associated with the cytokine receptors [13].

Chemical compound and disease context of STAM


Biological context of STAM

  • We previously identified three mammalian Vps (vacuolar protein sorting) proteins, Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and signal transducing adaptor molecule (STAM) 1 and -2, which are tyrosine-phosphorylated upon cytokine/growth factor stimulation [18].
  • EAST and STAM 2A/Hbp play a role in receptor-mediated endo- and exocytosis and probably also in the regulation of actin cytoskeleton [19].
  • TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM [20].
  • Revertant Hrs expression in hrs(-/-) cells not only led to the accumulation of ubiquitinated proteins, including intracytoplasmic vesicles, but also restored STAM1 levels in early endosomes and eliminated the enlarged endosome phenotype caused by the absence of Hrs [18].
  • We previously identified a putative signal transducing adaptor molecule, named STAM, that contains an Src homology 3 (SH3) domain and immunoreceptor tyrosine-based activation motif (ITAM) [13].

Anatomical context of STAM


Associations of STAM with chemical compounds


Physical interactions of STAM


Enzymatic interactions of STAM

  • An inactivating mutation (D348A) in AMSH leads to accumulation of ubiquitin on endosomes and the concomitant stabilization of a ubiquitinated form of STAM, which requires an intact ubiquitin interaction motif (UIM) within STAM [30].
  • Cytologic findings were retrospectively analyzed in the Papanicolaou-stained stamp smears obtained from the cut surfaces of thymoma specimens [31].

Co-localisations of STAM


Regulatory relationships of STAM

  • This molecule is 55% identical to a previously isolated molecule designated signal transducing adaptor molecule (STAM) that was identified as an interleukin (IL)-2-induced phosphoprotein and is therefore designated STAM2 [32].

Other interactions of STAM

  • STAM2, a new member of the STAM family, binding to the Janus kinases [33].
  • We have looked for similar activity in associated molecule with the SH3 domain of STAM (AMSH), a JAMM domain-containing protein that associates with the SH3-domain of STAM, a protein, which regulates receptor sorting at the endosome [30].
  • AMSH also interacts with mVps24/CHMP3, a component of ESCRT III complex, and this interaction is reinforced through simultaneous STAM binding [34].
  • We suggest that STAMP is an important new, downstream component of GR action in both gene activation and gene repression [26].
  • The levels of molecules whose expressions are associated with myc, such as STAM, prothymosin-alpha, and NFkappaB, were also analyzed [35].

Analytical, diagnostic and therapeutic context of STAM

  • We report here a direct interaction between DDP and STAM1, identified by yeast two-hybrid screening and confirmed by co-immunoprecipitation, fusion protein "pull downs," and nuclear redistribution assays [22].
  • The three-dimensional topology of the microfluidic network in the stamp makes this technique a versatile one with which to pattern multiple types of proteins and cells in complex, discontinuous structures on a surface [36].
  • Micromolar concentrations of the active STAMP metabolite in plasma were rapidly achieved and maintained for more than 4 h after parenteral as well as oral administration of a nontoxic 100-mg/kg bolus dose of STAMP [1].
  • In the phase 1/2 study, 75 breast cancer patients underwent a bone marrow harvest and myeloablative STAMP V chemotherapy and were randomized to receive placebo or one of three doses of PEG-rHuMGDF [37].
  • Participation in Supplemental Food Program for Women, Infants and Children program, food stamp benefits, and consumption of low-fat diets were associated (P < 0.05) with lower added sugars use [38].


  1. In vivo toxicity, pharmacokinetics, and anti-human immunodeficiency virus activity of stavudine-5'-(p-bromophenyl methoxyalaninyl phosphate) (stampidine) in mice. Uckun, F.M., Qazi, S., Pendergrass, S., Lisowski, E., Waurzyniak, B., Chen, C.L., Venkatachalam, T.K. Antimicrob. Agents Chemother. (2002) [Pubmed]
  2. Stampidine is a potent inhibitor of Zidovudine- and nucleoside analog reverse transcriptase inhibitor-resistant primary clinical human immunodeficiency virus type 1 isolates with thymidine analog mutations. Uckun, F.M., Pendergrass, S., Venkatachalam, T.K., Qazi, S., Richman, D. Antimicrob. Agents Chemother. (2002) [Pubmed]
  3. Enhancement of Antimicrobial Activity against Pseudomonas aeruginosa by Coadministration of G10KHc and Tobramycin. Eckert, R., Brady, K.M., Greenberg, E.P., Qi, F., Yarbrough, D.K., He, J., McHardy, I., Anderson, M.H., Shi, W. Antimicrob. Agents Chemother. (2006) [Pubmed]
  4. Long-term food stamp program participation is differentially related to overweight in young girls and boys. Gibson, D. J. Nutr. (2004) [Pubmed]
  5. Forced collectionism after orbitofrontal damage. Volle, E., Beato, R., Levy, R., Dubois, B. Neurology (2002) [Pubmed]
  6. The role of estrogens in schizophrenia gender differences. Seeman, M.V., Lang, M. Schizophrenia bulletin. (1990) [Pubmed]
  7. Use of the vital sign stamp as a systematic screening tool to promote smoking cessation. Piper, M.E., Fiore, M.C., Smith, S.S., Jorenby, D.E., Wilson, J.R., Zehner, M.E., Baker, T.B. Mayo Clin. Proc. (2003) [Pubmed]
  8. Immuno-electron-microscopic localization of complements in amyloid fibrils of senile plaques. Ishii, T., Haga, S. Acta Neuropathol. (1984) [Pubmed]
  9. Paper stamp checklist tool enhances asthma guidelines knowledge and implementation by primary care physicians. Renzi, P.M., Ghezzo, H., Goulet, S., Dorval, E., Thivierge, R.L. Can. Respir. J. (2006) [Pubmed]
  10. Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains. Misra, S., Puertollano, R., Kato, Y., Bonifacino, J.S., Hurley, J.H. Nature (2002) [Pubmed]
  11. Submicrometer patterning of charge in thin-film electrets. Jacobs, H.O., Whitesides, G.M. Science (2001) [Pubmed]
  12. Endocytosis: the DUB version. Clague, M.J., Urb??, S. Trends Cell Biol. (2006) [Pubmed]
  13. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction. Takeshita, T., Arita, T., Higuchi, M., Asao, H., Endo, K., Kuroda, H., Tanaka, N., Murata, K., Ishii, N., Sugamura, K. Immunity (1997) [Pubmed]
  14. Cardiac toxicity following high-dose cyclophosphamide, cisplatin, and BCNU (STAMP-I) for breast cancer. Nieto, Y., Cagnoni, P.J., Bearman, S.I., Shpall, E.J., Matthes, S., Jones, R.B. Biol. Blood Marrow Transplant. (2000) [Pubmed]
  15. A randomized trial of amifostine and carmustine-containing chemotherapy to assess lung-protective effects. Jones, R.B., Stockerl-Goldstein, K.E., Klein, J., Murphy, J., Blume, K.G., Dansey, R., Martinez, C., Matthes, S., Nieto, Y. Biol. Blood Marrow Transplant. (2004) [Pubmed]
  16. In vitro activity of stampidine against primary clinical human immunodeficiency virus isolates. Uckun, F.M., Pendergrass, S., Qazi, S., Venkatachalam, T.K. Arzneimittel-Forschung. (2004) [Pubmed]
  17. Quantitative analysis of microcirculatory disorders after prolonged ischemia in skeletal muscle. Therapeutic effects of prophylactic isovolemic hemodilution. Menger, M.D., Sack, F.U., Barker, J.H., Feifel, G., Messmer, K. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1988) [Pubmed]
  18. Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. Kobayashi, H., Tanaka, N., Asao, H., Miura, S., Kyuuma, M., Semura, K., Ishii, N., Sugamura, K. J. Biol. Chem. (2005) [Pubmed]
  19. STAM/EAST/Hbp adapter proteins--integrators of signalling pathways. Lohi, O., Lehto, V.P. FEBS Lett. (2001) [Pubmed]
  20. TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. Seroussi, E., Kedra, D., Kost-Alimova, M., Sandberg-Nordqvist, A.C., Fransson, I., Jacobs, J.F., Fu, Y., Pan, H.Q., Roe, B.A., Imreh, S., Dumanski, J.P. Genomics (1999) [Pubmed]
  21. STAM proteins bind ubiquitinated proteins on the early endosome via the VHS domain and ubiquitin-interacting motif. Mizuno, E., Kawahata, K., Kato, M., Kitamura, N., Komada, M. Mol. Biol. Cell (2003) [Pubmed]
  22. Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1. Blackstone, C., Roberts, R.G., Seeburg, D.P., Sheng, M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  23. Evaluation of the predictive value of Her-2/neu overexpression and p53 mutations in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplantation. Nieto, Y., Cagnoni, P.J., Nawaz, S., Shpall, E.J., Yerushalmi, R., Cook, B., Russell, P., McDermit, J., Murphy, J., Bearman, S.I., Jones, R.B. J. Clin. Oncol. (2000) [Pubmed]
  24. Joachim kohn (1912-1987) and the origin of cellulose acetate electrophoresis. Rocco, R.M. Clin. Chem. (2005) [Pubmed]
  25. Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Scoles, D.R., Nguyen, V.D., Qin, Y., Sun, C.X., Morrison, H., Gutmann, D.H., Pulst, S.M. Hum. Mol. Genet. (2002) [Pubmed]
  26. STAMP, a Novel Predicted Factor Assisting TIF2 Actions in Glucocorticoid Receptor-Mediated Induction and Repression. He, Y., Simons, S.S. Mol. Cell. Biol. (2007) [Pubmed]
  27. Chemically patterned flat stamps for microcontact printing. Sharpe, R.B., Burdinski, D., Huskens, J., Zandvliet, H.J., Reinhoudt, D.N., Poelsema, B. J. Am. Chem. Soc. (2005) [Pubmed]
  28. Association with Hrs is required for the early endosomal localization, stability, and function of STAM. Mizuno, E., Kawahata, K., Okamoto, A., Kitamura, N., Komada, M. J. Biochem. (2004) [Pubmed]
  29. Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes. Nakamura, M., Tanaka, N., Kitamura, N., Komada, M. Genes Cells (2006) [Pubmed]
  30. AMSH is an endosome-associated ubiquitin isopeptidase. McCullough, J., Clague, M.J., Urbé, S. J. Cell Biol. (2004) [Pubmed]
  31. Cytomorphologic features characteristic of tumor stages of thymomas. Baba, M., Nomoto, Y., Iyoda, A., Saito, H., Hiroshima, K., Shibuya, K., Haga, Y., Hoshino, H., Iizasa, T., Horiuchi, F., Fujisawa, T. Oncol. Rep. (2001) [Pubmed]
  32. Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. Pandey, A., Fernandez, M.M., Steen, H., Blagoev, B., Nielsen, M.M., Roche, S., Mann, M., Lodish, H.F. J. Biol. Chem. (2000) [Pubmed]
  33. STAM2, a new member of the STAM family, binding to the Janus kinases. Endo, K., Takeshita, T., Kasai, H., Sasaki, Y., Tanaka, N., Asao, H., Kikuchi, K., Yamada, M., Chenb, M., O'Shea, J.J., Sugamura, K. FEBS Lett. (2000) [Pubmed]
  34. Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. McCullough, J., Row, P.E., Lorenzo, O., Doherty, M., Beynon, R., Clague, M.J., Urbé, S. Curr. Biol. (2006) [Pubmed]
  35. Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients. Nagata, T., Onodera, H., Ohuchi, M., Suzuki, Y., Tago, H., Fujihara, K., Ishii, N., Sugamura, K., Shoji, Y., Handa, M., Tabayashi, K., Itoyama, Y. J. Neuroimmunol. (2001) [Pubmed]
  36. Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems. Chiu, D.T., Jeon, N.L., Huang, S., Kane, R.S., Wargo, C.J., Choi, I.S., Ingber, D.E., Whitesides, G.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  37. The effects of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) on platelet recovery in breast cancer patients undergoing autologous bone marrow transplantation. Schuster, M.W., Beveridge, R., Frei-Lahr, D., Abboud, C.N., Cruickshank, S., Macri, M., Menchaca, D., Holden, J., Waller, E.K. Exp. Hematol. (2002) [Pubmed]
  38. Added sugars displaced the use of vital nutrients in the national food stamp program survey. Bhargava, A., Amialchuk, A. J. Nutr. (2007) [Pubmed]
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