High impact information on Sema6d

• Ectopic expression of Sema6D o RNA interference against Sema6D induces expansion or narrowing of the ventricular chamber, respectively, during chick embryonic development [1].
• Here, we demonstrate a critical involvement of Sema6D in cardiac morphogenesis [1].
• Plexin-A1 forms a receptor complex with vascular endothelial growth factor receptor type 2 in the conotruncal segment or with Off-track in the ventricle segment; these complexes are responsible for the effects of Sema6D on the respective regions [1].
• In a ligand-dependent manner, Abl kinase is recruited to the cytoplasmic tail of Sema6D and activated, resulting in phosphorylation of Enabled and dissociation from Sema6D [2].
• Through ligation of the Plexin-A1 receptor, the transmembrane-type semaphorin Sema6D regulates endocardial cell migration [2].

Biological context of Sema6d

• Here we report murine orthologues of a novel member of class 6 semaphorin gene, semaphorin 6D (Sema6D), mapped on the chromosome 2 [3].
• Thus, Sema6D may play important roles in various functions including the axon guidance during development and neuronal plasticity [3].

Anatomical context of Sema6d

• This indicates that reverse signalling by Sema6D occurs within the myocardium [2].

Analytical, diagnostic and therapeutic context of Sema6d

• Sema6D is mainly expressed in the brain and lung, and the ubiquitous expression in the brain continues from embryonic late stage to adulthood, as determined by Northern blot and in situ hybridization [3].

References