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Gene Review:

Tph2 - tryptophan hydroxylase 2

Mus musculus

Synonyms: AU043594, Neuronal tryptophan hydroxylase, Ntph, Tryptophan 5-hydroxylase 2, Tryptophan 5-monooxygenase 2

Kulikov, A.V. et al., Crowley, J.J. et al., Cervo, L. et al., Clark, J.A. et al., Hong, K.W. et al.

Clark, Pai, Flick, Rohrer, Kulikov, Osipova, Naumenko, Popova,

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High impact information on Tph2

Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus [1].
As an initial search for genetic polymorphisms causing differences in citalopram sensitivity, polymorphic forms of the tryptophan hydroxylase 2 (tph2) gene were genotyped and found to be not correlated with citalopram responsive (DBA/2J and BALB/cJ) and nonresponsive (A/J and C57BL/6J) strains [2].
Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme of neuronal serotonin biosynthesis [3].
The results support a link between the C1473G polymorphism in Tph2 gene, tryptophan hydroxylase activity and intensity of intermale aggression [4].
Recently the C1473G single-nucleotide polymorphism in the Tph2 gene was reported [4].

Associations of Tph2 with chemical compounds

The main factor determining the brain serotonin level is the activity of the rate-limiting enzyme in the biosynthesis of the neurotransmitter--tryptophan hydroxylase isoform (TPH) 2 encoded by the Tph2 gene [4].
Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression [5].

References

Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Clark, J.A., Pai, L.Y., Flick, R.B., Rohrer, S.P. Biol. Psychiatry (2005) [Pubmed]
Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test. Crowley, J.J., Blendy, J.A., Lucki, I. Psychopharmacology (Berl.) (2005) [Pubmed]
A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats. Hong, K.W., Sugawara, Y., Hasegawa, H., Hayasaka, I., Hashimoto, R., Ito, S., Inoue-Murayama, M. Neurosci. Lett. (2007) [Pubmed]
Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains. Kulikov, A.V., Osipova, D.V., Naumenko, V.S., Popova, N.K. Genes Brain Behav. (2005) [Pubmed]
Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression. Cervo, L., Canetta, A., Calcagno, E., Burbassi, S., Sacchetti, G., Caccia, S., Fracasso, C., Albani, D., Forloni, G., Invernizzi, R.W. J. Neurosci. (2005) [Pubmed]

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tph-1	Caenorhabditis elegans
TPH2	Canis lupus familiaris
tph2	Danio rerio
TPH2	Gallus gallus
TPH2	Homo sapiens
TPH2	Macaca mulatta
TPH2	Pan troglodytes
Tph2	Rattus norvegicus
tph2	Xenopus (Silurana) tropicalis

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