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Gene Review

Tph2  -  tryptophan hydroxylase 2

Mus musculus

Synonyms: AU043594, Neuronal tryptophan hydroxylase, Ntph, Tryptophan 5-hydroxylase 2, Tryptophan 5-monooxygenase 2
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High impact information on Tph2


Associations of Tph2 with chemical compounds

  • The main factor determining the brain serotonin level is the activity of the rate-limiting enzyme in the biosynthesis of the neurotransmitter--tryptophan hydroxylase isoform (TPH) 2 encoded by the Tph2 gene [4].
  • Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression [5].


  1. Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Clark, J.A., Pai, L.Y., Flick, R.B., Rohrer, S.P. Biol. Psychiatry (2005) [Pubmed]
  2. Strain-dependent antidepressant-like effects of citalopram in the mouse tail suspension test. Crowley, J.J., Blendy, J.A., Lucki, I. Psychopharmacology (Berl.) (2005) [Pubmed]
  3. A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats. Hong, K.W., Sugawara, Y., Hasegawa, H., Hayasaka, I., Hashimoto, R., Ito, S., Inoue-Murayama, M. Neurosci. Lett. (2007) [Pubmed]
  4. Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains. Kulikov, A.V., Osipova, D.V., Naumenko, V.S., Popova, N.K. Genes Brain Behav. (2005) [Pubmed]
  5. Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression. Cervo, L., Canetta, A., Calcagno, E., Burbassi, S., Sacchetti, G., Caccia, S., Fracasso, C., Albani, D., Forloni, G., Invernizzi, R.W. J. Neurosci. (2005) [Pubmed]
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