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Gene Review

Tph1  -  tryptophan hydroxylase 1

Mus musculus

Synonyms: Tph, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1
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Disease relevance of Tph1


Psychiatry related information on Tph1


High impact information on Tph1


Chemical compound and disease context of Tph1


Biological context of Tph1


Anatomical context of Tph1


Associations of Tph1 with chemical compounds


Regulatory relationships of Tph1

  • TPH was induced by PRL in mammosphere cultures and by milk stasis in nursing dams, suggesting that the gene is controlled by milk filling in the alveoli [17].
  • The activity of tryptophan 5-monooxygenase was selectively enhanced 4.5-fold by the combination of IL-3 with KL [24].
  • H13/04 was subsequently shown to competitively inhibit tryptophan hydroxylase [25].
  • Here we investigated the effect of genetic deletion of tryptophan hydroxylase 1 on hypoxia-induced pulmonary arterial hypertension in mice by measuring pulmonary hemodynamics and pulmonary vascular remodeling before and after 2 weeks of hypoxia [26].

Other interactions of Tph1


Analytical, diagnostic and therapeutic context of Tph1


  1. Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase. Peter, J.U., Alenina, N., Bader, M., Walther, D.J. Mol. Cell. Biochem. (2007) [Pubmed]
  2. Serotoninergic system in hamster skin. Slominski, A., Pisarchik, A., Semak, I., Sweatman, T., Szczesniewski, A., Wortsman, J. J. Invest. Dermatol. (2002) [Pubmed]
  3. Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line. Stoll, J., Kozak, C.A., Goldman, D. Genomics (1990) [Pubmed]
  4. A 6.1 kb 5' upstream region of the mouse tryptophan hydroxylase gene directs expression of E. coli lacZ to major serotonergic brain regions and pineal gland in transgenic mice. Huh, S.O., Park, D.H., Cho, J.Y., Joh, T.H., Son, J.H. Brain Res. Mol. Brain Res. (1994) [Pubmed]
  5. Enantiospecific syntheses of alpha-(fluoromethyl)tryptophan analogues: interactions with tryptophan hydroxylase and aromatic L-amino acid decarboxylase. Zembower, D.E., Gilbert, J.A., Ames, M.M. J. Med. Chem. (1993) [Pubmed]
  6. Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease. Yohrling IV, G.J., Jiang, G.C., DeJohn, M.M., Robertson, D.J., Vrana, K.E., Cha, J.H. J. Neurochem. (2002) [Pubmed]
  7. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Walther, D.J., Peter, J.U., Winter, S., Höltje, M., Paulmann, N., Grohmann, M., Vowinckel, J., Alamo-Bethencourt, V., Wilhelm, C.S., Ahnert-Hilger, G., Bader, M. Cell (2003) [Pubmed]
  8. Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Esaki, T., Cook, M., Shimoji, K., Murphy, D.L., Sokoloff, L., Holmes, A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Nielsen, D.A., Dean, M., Goldman, D. Am. J. Hum. Genet. (1992) [Pubmed]
  10. Serotonin initiates and autoamplifies its own synthesis during mouse central nervous system development. De Vitry, F., Hamon, M., Catelon, J., Dubois, M., Thibault, J. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  11. Elevated aromatic-L-amino acid decarboxylase in human carcinoid tumors. Gilbert, J.A., Bates, L.A., Ames, M.M. Biochem. Pharmacol. (1995) [Pubmed]
  12. Serotoninergic involvement in ethanol-induced alterations of thermoregulation in long-sleep and short-sleep mice. French, T.A., Weiner, N. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  13. Inhibition of tryptophan hydroxylase by (R)- and (S)-1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines (salsolinols). Ota, M., Dostert, P., Hamanaka, T., Nagatsu, T., Naoi, M. Neuropharmacology (1992) [Pubmed]
  14. On the role of brain serotonin in expression of genetic predisposition to catalepsy in animal models. Popova, N.K., Kulikov, A.V. Am. J. Med. Genet. (1995) [Pubmed]
  15. Direct central effects of acute methylenedioxymethamphetamine on serotonergic neurons. Schmidt, C.J., Taylor, V.L. Eur. J. Pharmacol. (1988) [Pubmed]
  16. Differential tissue distribution of tryptophan hydroxylase isoforms 1 and 2 as revealed with monospecific antibodies. Sakowski, S.A., Geddes, T.J., Thomas, D.M., Levi, E., Hatfield, J.S., Kuhn, D.M. Brain Res. (2006) [Pubmed]
  17. Serotonin regulates mammary gland development via an autocrine-paracrine loop. Matsuda, M., Imaoka, T., Vomachka, A.J., Gudelsky, G.A., Hou, Z., Mistry, M., Bailey, J.P., Nieport, K.M., Walther, D.J., Bader, M., Horseman, N.D. Dev. Cell (2004) [Pubmed]
  18. Estrogen receptor-beta regulates tryptophan hydroxylase-1 expression in the murine midbrain raphe. Gundlah, C., Alves, S.E., Clark, J.A., Pai, L.Y., Schaeffer, J.M., Rohrer, S.P. Biol. Psychiatry (2005) [Pubmed]
  19. Importance of leucine zipper domain of mi transcription factor (MITF) for differentiation of mast cells demonstrated using mi(ce)/mi(ce) mutant mice of which MITF lacks the zipper domain. Morii, E., Ogihara, H., Kim, D.K., Ito, A., Oboki, K., Lee, Y.M., Jippo, T., Nomura, S., Maeyama, K., Lamoreux, M.L., Kitamura, Y. Blood (2001) [Pubmed]
  20. Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus. Clark, J.A., Pai, L.Y., Flick, R.B., Rohrer, S.P. Biol. Psychiatry (2005) [Pubmed]
  21. Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus. Lacoste, B., Riad, M., Descarries, L. Eur. J. Neurosci. (2006) [Pubmed]
  22. (+)-Norfenfluramine-induced arterial contraction is not dependent on endogenous 5-hydroxytryptamine or 5-hydroxytryptamine transporter. Ni, W., Wilhelm, C.S., Bader, M., Murphy, D.L., Lookingland, K., Watts, S.W. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  23. Serotonergic neurons in the peripheral nervous system: identification in gut by immunohistochemical localization of tryptophan hydroxylase. Gershon, M.D., Dreyfus, C.F., Pickel, V.M., Joh, T.H., Reis, D.J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  24. In a concerted action kit ligand and interleukin 3 control the synthesis of serotonin in murine bone marrow-derived mast cells. Up-regulation of GTP cyclohydrolase I and tryptophan 5-monooxygenase activity by the kit ligand. Ziegler, I., Hültner, L., Egger, D., Kempkes, B., Mailhammer, R., Gillis, S., Rödl, W. J. Biol. Chem. (1993) [Pubmed]
  25. Inhibition of tryptophan hydroxylase: neurochemical action of catecholamide seizure-inducing agent. Stine, S., Kellogg, C. Neurochem. Res. (1982) [Pubmed]
  26. Effect of tryptophan hydroxylase 1 deficiency on the development of hypoxia-induced pulmonary hypertension. Morecroft, I., Dempsie, Y., Bader, M., Walther, D.J., Kotnik, K., Loughlin, L., Nilsen, M., MacLean, M.R. Hypertension (2007) [Pubmed]
  27. Systematic method to obtain novel genes that are regulated by mi transcription factor: impaired expression of granzyme B and tryptophan hydroxylase in mi/mi cultured mast cells. Ito, A., Morii, E., Maeyama, K., Jippo, T., Kim, D.K., Lee, Y.M., Ogihara, H., Hashimoto, K., Kitamura, Y., Nojima, H. Blood (1998) [Pubmed]
  28. Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ER alpha) gene-disrupted mice. Alves, S.E., McEwen, B.S., Hayashi, S., Korach, K.S., Pfaff, D.W., Ogawa, S. J. Comp. Neurol. (2000) [Pubmed]
  29. Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains. Kulikov, A.V., Osipova, D.V., Naumenko, V.S., Popova, N.K. Genes Brain Behav. (2005) [Pubmed]
  30. Serotonin synthesis in murine embryonic stem cells. Walther, D.J., Bader, M. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  31. Differential distribution of estrogen receptor (ER)-alpha and ER-beta in the midbrain raphe nuclei and periaqueductal gray in male mouse: Predominant role of ER-beta in midbrain serotonergic systems. Nomura, M., Akama, K.T., Alves, S.E., Korach, K.S., Gustafsson, J.A., Pfaff, D.W., Ogawa, S. Neuroscience (2005) [Pubmed]
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