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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TPH2  -  tryptophan hydroxylase 2

Macaca mulatta

 
 
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High impact information on TPH2

  • Tryptophan hydroxylase-2 (TPH2) is a newly identified second form of TPH responsible for serotonin synthesis in the brain and has been increasingly implicated as a contributor to the etiology of various psychiatric disorders [1].
  • In this study, we have identified the constellation of polymorphisms in rhesus monkey TPH2 and investigated genotype/phenotype association as well as gene expression effects of specific polymorphisms [1].
  • Polymorphisms in all exons, splicing junctions and approximately 2 kb of the 5'-flanking region (5'-FR) of TPH2 were identified by sequencing [1].
  • Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression [1].
  • In the ISH assay, all of the hormone treatments caused a significant and similar increase in TPH-2 mRNA optical density (fourfold; P < 0.004) and positive pixel area (twofold; P < 0.002) over spayed controls [2].
 

Analytical, diagnostic and therapeutic context of TPH2

  • Additional monkeys (n = 3/treatment) were used to determine the relative abundance of TPH-2 mRNA with quantitative (q) RT-PCR [2].

References

  1. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Chen, G.L., Novak, M.A., Hakim, S., Xie, Z., Miller, G.M. Mol. Psychiatry (2006) [Pubmed]
  2. A second tryptophan hydroxylase isoform, TPH-2 mRNA, is increased by ovarian steroids in the raphe region of macaques. Sanchez, R.L., Reddy, A.P., Centeno, M.L., Henderson, J.A., Bethea, C.L. Brain Res. Mol. Brain Res. (2005) [Pubmed]
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