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Gene Review

Tph2  -  tryptophan hydroxylase 2

Rattus norvegicus

Synonyms: Neuronal tryptophan hydroxylase, Ntph, Tryptophan 5-hydroxylase 2, Tryptophan 5-monooxygenase 2
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High impact information on Tph2


Biological context of Tph2


Chemical compound and disease context of Tph2


Associations of Tph2 with chemical compounds

  • Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis [5].

Analytical, diagnostic and therapeutic context of Tph2

  • To that end, we measured Tph1 (classical Tph) and Tph2 mRNA levels using real-time quantitative RT-PCR in the retina [4].


  1. Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Hiroi, R., McDevitt, R.A., Neumaier, J.F. Biol. Psychiatry (2006) [Pubmed]
  2. Fast erg K+ currents in rat embryonic serotonergic neurones. Hirdes, W., Schweizer, M., Schuricht, K.S., Guddat, S.S., Wulfsen, I., Bauer, C.K., Schwarz, J.R. J. Physiol. (Lond.) (2005) [Pubmed]
  3. Identification of genes regulated by chronic social stress in the rat dorsal raphe nucleus. Abumaria, N., Rygula, R., Havemann-Reinecke, U., Rüther, E., Bodemer, W., Roos, C., Flügge, G. Cell. Mol. Neurobiol. (2006) [Pubmed]
  4. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Liang, J., Wessel, J.H., Iuvone, P.M., Tosini, G., Fukuhara, C. Neuroreport (2004) [Pubmed]
  5. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Zhang, X., Beaulieu, J.M., Sotnikova, T.D., Gainetdinov, R.R., Caron, M.G. Science (2004) [Pubmed]
  6. Daily rhythm of tryptophan hydroxylase-2 messenger ribonucleic acid within raphe neurons is induced by corticoid daily surge and modulated by enhanced locomotor activity. Malek, Z.S., Sage, D., Pévet, P., Raison, S. Endocrinology (2007) [Pubmed]
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