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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Tpst1  -  protein-tyrosine sulfotransferase 1

Mus musculus

Synonyms: Protein-tyrosine sulfotransferase 1, R75054, TPST-1, Tango13a, Tyrosylprotein sulfotransferase 1
 
 
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Disease relevance of Tpst1

  • Tpst1(-/-) mice appear healthy but have approximately 5% lower average body weight than Tpst1(+/+) controls [1].
  • In addition, we show that although fertility of Tpst1(-/-) males and females per se is normal, Tpst1(-/-) females have significantly smaller litters because of fetal death between 8.5 and 15.5 days postcoitum [1].
  • This indicates that TPST1 and TPST2 have distinct macromolecular substrate specificities and provides clues as to the molecular mechanism of the infertility of Tpst2(-/-) males [2].
 

High impact information on Tpst1

  • Protein tyrosine O-sulfation is a post-translational modification mediated by one of two Golgi tyrosylprotein sulfotransferases (TPST1 and TPST2) that catalyze the transfer of sulfate to tyrosine residues in secreted and transmembrane proteins [2].
  • Tyrosine sulfation is mediated by one of two Golgi isoenzymes, called tyrosylprotein sulfotransferases (TPST-1 and TPST-2) [1].
  • To gain insight into the structural requirements for tyrosine sulfation in vivo, we have constructed and expressed an artificial gene encoding a polypeptide substrate for tyrosylprotein sulfotransferase [3].
  • In the accompanying paper (Friederich, E., Baeuerle, P. A., Garoff, H., Hovemann, B., and Huttner, W. B. (1988) J. Biol. Chem. 263, 14930-14938), we report on the expression of Drosophila yolk protein 2 in mouse fibroblasts and show the in vivo sulfation of tyrosine 172 by the vertebrate tyrosylprotein sulfotransferase [4].
 

Biological context of Tpst1

  • Our findings also strongly support the conclusion that TPST-1 and TPST-2 have distinct biological roles that may reflect differences in their macromolecular substrate specificity [1].

References

  1. Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. Ouyang, Y.B., Crawley, J.T., Aston, C.E., Moore, K.L. J. Biol. Chem. (2002) [Pubmed]
  2. Detection and Purification of Tyrosine-sulfated Proteins Using a Novel Anti-sulfotyrosine Monoclonal Antibody. Hoffhines, A.J., Damoc, E., Bridges, K.G., Leary, J.A., Moore, K.L. J. Biol. Chem. (2006) [Pubmed]
  3. In vivo expression and stoichiometric sulfation of the artificial protein sulfophilin, a polymer of tyrosine sulfation sites. Niehrs, C., Huttner, W.B., Rüther, U. J. Biol. Chem. (1992) [Pubmed]
  4. Purification of yolk protein 2 of Drosophila melanogaster and identification of its site of tyrosine sulfation. Baeuerle, P.A., Lottspeich, F., Huttner, W.B. J. Biol. Chem. (1988) [Pubmed]
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