The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PI16  -  peptidase inhibitor 16

Homo sapiens

Synonyms: CRISP-9, CRISP9, Cysteine-rich secretory protein 9, MGC45378, MSMBBP, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PI16


High impact information on PI16

  • Total PSP94, free PSP94, and the PSPBP were quantified in the pretreatment serum using new ELISA tests (Medicorp, Inc. and Ambrilia Biopharma, Inc., Montreal, Quebec, Canada) [2].
  • CONCLUSIONS: Bound/free PSP94 and PSPBP are novel and independent prognostic markers following radical prostatectomy for prostate cancer [2].
  • RESULTS: Use of tamoxifen prolonged the average survival of cohort members by 69 days (95% probability interval [PI] 27 to 117) for those who started use at age 35 years; 40 days (95% PI 16 to 67) for those who started use at age 50 years; and 27 days (95% PI 14 to 40) for those who started use at age 60 years [3].
  • Immunohistochemistry demonstrated PSPBP in tissues, including pituitary and Leydig cells, supporting a role for PSP94 in hormonal control at the pituitary gonadal axis [1].
  • Reverse transcriptase PCR and plaque hybridization demonstrated PSPBP mRNA in peripheral blood leucocytes and in a prostate cDNA library [1].

Other interactions of PI16

  • PSPBP identification will help the understanding of PSP94's functions and facilitate ELISA development to address the clinical value of PSP94 serum assays [1].

Analytical, diagnostic and therapeutic context of PI16


  1. Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. Reeves, J.R., Xuan, J.W., Arfanis, K., Morin, C., Garde, S.V., Ruiz, M.T., Wisniewski, J., Panchal, C., Tanner, J.E. Biochem. J. (2005) [Pubmed]
  2. Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. Reeves, J.R., Dulude, H., Panchal, C., Daigneault, L., Ramnani, D.M. Clin. Cancer Res. (2006) [Pubmed]
  3. Decision analysis of tamoxifen for the prevention of invasive breast cancer. Grann, V.R., Sundararajan, V., Jacobson, J.S., Whang, W., Heitjan, D.F., Antman, K.H., Neugut, A.I. Cancer journal (Sudbury, Mass.) (2000) [Pubmed]
WikiGenes - Universities