The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Ercc5  -  excision repair cross-complementing rodent...

Mus musculus

Synonyms: DNA excision repair protein ERCC-5, DNA repair protein complementing XP-G cells homolog, Ercc-5, Xeroderma pigmentosum group G-complementing protein homolog, Xpg
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Ercc5

 

High impact information on Ercc5

  • The control mice, in which one-half of Xpg genomic DNA fragment was replaced with a normal Xpg cDNA fragment, had a normal growth rate, a normal life span, normal sensitivity to UV light, and normal DNA repair ability, indicating that the Xpg gene partially replaced with the normal cDNA fragment retained normal functions [1].
  • The XpgD811stop homozygous mice, however, exhibited a slightly milder CS phenotype than did the Xpg null mutant mice, indicating that the XpgD811stop protein still retains some Xpg function that affects the severity of the CS phenotype [1].
  • The distribution of the mutations observed in the lacZ transgene and the preferred sequence context of the UV-specific C --> T mutations (5'-TC-3' > 5'-CC-3' > 5'-CT-3') in the Xpg-mutant mice were similar to those found in the wild-type mice [3].
  • To clarify this point, we determined spontaneous mutation frequencies and the type of spontaneous base substitution mutations in cells obtained from normal and Xpg-deficient mice using the supF shuttle vector (pNY200) for mutation assay [4].
  • Cells isolated from Xpg (the mouse counterpart of XPG)-disrupted mice underwent premature senescence and showed early onset of immortalization, suggesting that Xpg might be involved in genetic stability [4].
 

Biological context of Ercc5

  • The XpgD811stop homozygous mice exhibited growth retardation and a short life span, but the Xpg Delta ex15 homozygous mice did not, indicating that deletion of the last 360 amino acids results in the CS phenotype but deletion of the last 183 amino acids does not [1].
  • When we compared amino acid sequences corresponding to the exon 15 of Xpg, a significant homology was conserved among vertebrates, but not in Drosophila and Saccharomyces cerevisiae [5].
 

Associations of Ercc5 with chemical compounds

  • Recent studies showed that human XPG, in addition to its function in the nucleotide excision repair (NER), was involved in the repair of oxidative base damages such as thymine glycol (Tg) and 8-oxo-guanine (8-oxoG), and this may explain the genetic instability observed in Xpg-deficient cells [4].
 

Other interactions of Ercc5

  • Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg [5].

References

  1. Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method. Shiomi, N., Kito, S., Oyama, M., Matsunaga, T., Harada, Y.N., Ikawa, M., Okabe, M., Shiomi, T. Mol. Cell. Biol. (2004) [Pubmed]
  2. Microarray analysis in the HSV-1 latently infected mouse trigeminal ganglion. Higaki, S., Deai, T., Fukuda, M., Shimomura, Y. Cornea (2004) [Pubmed]
  3. Mutation spectrum in UVB-exposed skin epidermis of a mildly-affected Xpg-deficient mouse. Wang, F., Saito, Y., Shiomi, T., Yamada, S., Ono, T., Ikehata, H. Environ. Mol. Mutagen. (2006) [Pubmed]
  4. Disruption of Xpg increases spontaneous mutation frequency, particularly A:T to C:G transversion. Shiomi, N., Hayashi, E., Sasanuma, S., Mita, K., Shiomi, T. Mutat. Res. (2001) [Pubmed]
  5. Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg. Shiomi, N., Mori, M., Kito, S., Harada, Y.N., Tanaka, K., Shiomi, T. DNA Repair (Amst.) (2005) [Pubmed]
 
WikiGenes - Universities