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Gene Review

Ywhae  -  tyrosine 3-monooxygenase/tryptophan 5...

Mus musculus

Synonyms: 14-3-3 epsilon, 14-3-3 protein epsilon, 14-3-3E, AU019196
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Disease relevance of Ywhae


High impact information on Ywhae

  • Here, we show that the gene encoding 14-3-3epsilon (YWHAE), one of a family of ubiquitous phosphoserine/threonine-binding proteins, is always deleted in individuals with MDS [2].
  • Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon [3].
  • The results as a whole thus argue for the 14-3-3 epsilon isoform playing roles in neural development and in early mesenchyme, with this latter function being lost or replaced as the tissue differentiates [4].
  • Human heart cDNA sequencing yielded a cDNA clone that is similar in DNA and amino acid sequences to that of mouse 14-3-3 epsilon isoform [5].
  • It is likely that the 30-kDa protein detected in the rat tissues by the antibodies is the 14-3-3 protein epsilon-subunit [6].

Analytical, diagnostic and therapeutic context of Ywhae


  1. The 14-3-3 protein epsilon isoform expressed in reactive astrocytes in demyelinating lesions of multiple sclerosis binds to vimentin and glial fibrillary acidic protein in cultured human astrocytes. Satoh, J., Yamamura, T., Arima, K. Am. J. Pathol. (2004) [Pubmed]
  2. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Toyo-oka, K., Shionoya, A., Gambello, M.J., Cardoso, C., Leventer, R., Ward, H.L., Ayala, R., Tsai, L.H., Dobyns, W., Ledbetter, D., Hirotsune, S., Wynshaw-Boris, A. Nat. Genet. (2003) [Pubmed]
  3. Protein kinase C-alpha regulates insulin action and degradation by interacting with insulin receptor substrate-1 and 14-3-3 epsilon. Oriente, F., Andreozzi, F., Romano, C., Perruolo, G., Perfetti, A., Fiory, F., Miele, C., Beguinot, F., Formisano, P. J. Biol. Chem. (2005) [Pubmed]
  4. The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation. McConnell, J.E., Armstrong, J.F., Hodges, P.E., Bard, J.B. Dev. Biol. (1995) [Pubmed]
  5. Developmental regulation of 14-3-3 epsilon isoform in rat heart. Luk, S.C., Ngai, S.M., Tsui, S.K., Chan, K.K., Fung, K.P., Lee, C.Y., Waye, M.M. J. Cell. Biochem. (1998) [Pubmed]
  6. Identification of a rat 30-kDa protein recognized by the antibodies to a recombinant rat cutaneous fatty acid-binding protein as a 14-3-3 protein. Odani, S., Nakamura, J., Sato, T., Fujii, H. J. Biochem. (2001) [Pubmed]
  7. 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region. Chong, S.S., Tanigami, A., Roschke, A.V., Ledbetter, D.H. Genome Res. (1996) [Pubmed]
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