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Gene Review

14-3-3epsilon  -  CG31196 gene product from transcript...

Drosophila melanogaster

Synonyms: 14-3-3, 14-3-3 epsilon, 14-3-3 protein epsilon, 14-3-3-e, 14-3-3-epsilon, ...
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High impact information on 14-3-3epsilon

  • In epithelia, this complex localizes apically and defines the apical membrane, whereas Bazooka lacking PAR-1 phosphorylation/14-3-3 binding sites forms ectopic lateral complexes [1].
  • We show that several Drosophila homologs of checkpoint genes, mei-41, grapes, and 14-3-3epsilon, regulate a DNA damage checkpoint in the developing eye [2].
  • The 14-3-3 epsilon protein appears to function in multiple RTK pathways, suggesting that it is a general component of RAS1 signaling cascade [3].
  • Our genetic data suggest that 14-3-3 epsilon functions downstream of or parallel to RAF, but upstream of nuclear factors in RAS1 signaling [3].
  • We have isolated mutations in the gene encoding a Drosophila 14-3-3 epsilon protein as suppressors of the rough eye phenotype caused by the ectopic expression of RAS1(V12) [3].

Biological context of 14-3-3epsilon

  • Dynamic expression and cellular localization of the drosophila 14-3-3epsilon during embryonic development [4].
  • Relocalization of 14-3-3 proteins with cell cycle progression suggested cell-cycle-specific roles [5].
  • We suggest a model in which 14-3-3 proteins act in the undisturbed cell cycle to set a threshold for entry into mitosis by suppressing Cdk1 activity, to block mitosis following radiation damage and to facilitate proper exit from mitosis [5].
  • PAR-1 kinases phosphorylate proteins to generate 14-3-3 binding sites and may therefore directly deliver 14-3-3 to these targets [6].

Anatomical context of 14-3-3epsilon


Associations of 14-3-3epsilon with chemical compounds

  • 14-3-3 proteins form a highly conserved protein family whose members have been shown to activate tyrosine and tryptophan hydroxylases, inhibit protein kinase C and possess phospholipase A2 activity in vitro [7].

Other interactions of 14-3-3epsilon


Analytical, diagnostic and therapeutic context of 14-3-3epsilon

  • Northern blot analysis of poly(A)+ RNA isolated from eight different human tissues shows that 14-3-3 protein mRNAs are expressed in many tissues in the body [7].


  1. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Benton, R., St Johnston, D. Cell (2003) [Pubmed]
  2. mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development. Brodsky, M.H., Sekelsky, J.J., Tsang, G., Hawley, R.S., Rubin, G.M. Genes Dev. (2000) [Pubmed]
  3. 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila. Chang, H.C., Rubin, G.M. Genes Dev. (1997) [Pubmed]
  4. Dynamic expression and cellular localization of the drosophila 14-3-3epsilon during embryonic development. Tien, A.C., Hsei, H.Y., Chien, C.T. Mech. Dev. (1999) [Pubmed]
  5. Cell cycle roles for two 14-3-3 proteins during Drosophila development. Su, T.T., Parry, D.H., Donahoe, B., Chien, C.T., O'Farrell, P.H., Purdy, A. J. Cell. Sci. (2001) [Pubmed]
  6. Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation. Benton, R., Palacios, I.M., St Johnston, D. Dev. Cell (2002) [Pubmed]
  7. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. Swanson, K.D., Dhar, M.S., Joshi, J.G. Biochim. Biophys. Acta (1993) [Pubmed]
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