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Gene Review:

Zfp59 - zinc finger protein 59

Mus musculus

Synonyms: Mfg-2, Mfg2, Zfp-59, Zinc finger protein 59, Zinc finger protein Mfg-2

Passananti, C. et al.

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High impact information on Zfp59

At its NH2 terminus, Zfp59 shares with other members of the zinc finger gene family two additional conserved amino acid modules A and B, described as either FAX, KRAB, or FPB domains [1].
The product of Zfp59 (Mfg2), a mouse gene expressed at the spermatid stage of spermatogenesis, accumulates in spermatozoa nuclei [1].
The predicted amino acid sequence of the Zfp59 protein has been found to consist of 16 zinc-finger motifs clustered at the COOH terminus and subdivided into two groups by a degenerate finger motif [1].
By immunoelectron microscopy, the Zfp59 protein has been shown to accumulate in the nuclei of mature sperms in association with the nuclear matrix [1].
By means of Northern blot, Western blot analysis, and immunohistochemical localization, Zfp59 mRNA and its translation product were shown to be synthesized specifically during the postmeiotic phase of male germ line differentiation [1].

References

The product of Zfp59 (Mfg2), a mouse gene expressed at the spermatid stage of spermatogenesis, accumulates in spermatozoa nuclei. Passananti, C., Corbi, N., Paggi, M.G., Russo, M.A., Perez, M., Cotelli, F., Stefanini, M., Amati, P. Cell Growth Differ. (1995) [Pubmed]

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