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Gene Review

RASA3  -  RAS p21 protein activator 3

Homo sapiens

Synonyms: GAP1(IP4BP), GAP1IP4BP, GAPIII, Ins P4-binding protein, Ras GTPase-activating protein 3
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High impact information on RASA3


Biological context of RASA3

  • A 104 kDa InsP4 binding protein (KD for InsP4 = 12 nM), probably identical to GAP1IP4BP described by Cullen, Hsuan, Truong, Letcher, Jackson, Dawson and Irvine [(1995) Nature (London) 376, 527-530], was also isolated [4].

Associations of RASA3 with chemical compounds

  • Previously we have shown that although the PH domains of the Ras GTPase-activating proteins GAP1m and GAP1IP4BP are 63% identical at the amino acid level they possess distinct phosphoinositide-binding profiles [1].
  • The data indicate that under these conditions InsP4 is acting independently of cell type, of the ratio of inositol trisphosphate receptor subtypes, and of the concentration of GAP1IP4BP [5].

Other interactions of RASA3


  1. Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain. Cozier, G.E., Bouyoucef, D., Cullen, P.J. J. Biol. Chem. (2003) [Pubmed]
  2. Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis. Walker, S.A., Kupzig, S., Lockyer, P.J., Bilu, S., Zharhary, D., Cullen, P.J. J. Biol. Chem. (2002) [Pubmed]
  3. GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association. Cozier, G.E., Lockyer, P.J., Reynolds, J.S., Kupzig, S., Bottomley, J.R., Millard, T.H., Banting, G., Cullen, P.J. J. Biol. Chem. (2000) [Pubmed]
  4. Isolation of InsP4 and InsP6 binding proteins from human platelets: InsP4 promotes Ca2+ efflux from inside-out plasma membrane vesicles containing 104 kDa GAP1IP4BP protein. O'Rourke, F., Matthews, E., Feinstein, M.B. Biochem. J. (1996) [Pubmed]
  5. Expression level of inositol trisphosphate and inositol tetrakisphosphate receptors and their influence on Ca2+ release in permeabilized HL-60 and T15 cells. Dreikhausen, U.E., Dawson, A.P. Cell Calcium (2000) [Pubmed]
  6. Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. Lockyer, P.J., Bottomley, J.R., Reynolds, J.S., McNulty, T.J., Venkateswarlu, K., Potter, B.V., Dempsey, C.E., Cullen, P.J. Curr. Biol. (1997) [Pubmed]
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