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Gene Review

RASA2  -  RAS p21 protein activator 2

Homo sapiens

Synonyms: GAP1M, GAP1m, GTPase-activating protein 1m, RASGAP, Ras GTPase-activating protein 2
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Disease relevance of RASA2

  • A complete cDNA of human GAP1m was constructed by a series of reverse transcription-polymerase chain reaction (RT-PCR) using total RNA from human epidermoid carcinoma A431 cells [1].

High impact information on RASA2


Biological context of RASA2

  • When cDNA encoding rat rasGTPase-activating protein (rat GAP1m) was used as a probe, two partial cDNA clones of a human counterpart of rat GAP1m were isolated from a cDNA library derived from growth-arrested normal human ectocervical epithelial cells [1].

Associations of RASA2 with chemical compounds


  1. Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization. Kobayashi, M., Masui, T., Kusuda, J., Kameoka, Y., Hashimoto, K., Iwashita, S. Gene (1996) [Pubmed]
  2. Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain. Cozier, G.E., Bouyoucef, D., Cullen, P.J. J. Biol. Chem. (2003) [Pubmed]
  3. cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras. Li, S., Satoh, H., Watanabe, T., Nakamura, S., Hattori, S. Genomics (1996) [Pubmed]
  4. Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting. Lockyer, P.J., Bottomley, J.R., Reynolds, J.S., McNulty, T.J., Venkateswarlu, K., Potter, B.V., Dempsey, C.E., Cullen, P.J. Curr. Biol. (1997) [Pubmed]
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