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Gene Review:

SNX13 - sorting nexin 13

Homo sapiens

Synonyms: KIAA0713, RGS domain-and PHOX domain-containing protein, RGS-PX1, Sorting nexin-13

Zheng, B. et al., von Zastrow, M. et al., Zheng, B. et al.

von Zastrow, Mostov,

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High impact information on SNX13

RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking [1].
Expression of RGS-PX1 delayed lysosomal degradation of the EGF receptor [1].
The RGS domain of RGS-PX1 specifically interacted with Galpha(s), accelerated its GTP hydrolysis, and attenuated Galpha(s)-mediated signaling [1].
In a Perspective, von Zastrow and Mostov describe new work that identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by G protein-coupled receptors with membrane trafficking events [2].
By immunofluorescence, exogenously expressed Galphas colocalizes with myc-Hrs and GFP-RGS-PX1 on early endosomes, and expression of either Hrs or RGS-PX1 increases the localization of Galphas on endosomes [3].

References

RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Zheng, B., Ma, Y.C., Ostrom, R.S., Lavoie, C., Gill, G.N., Insel, P.A., Huang, X.Y., Farquhar, M.G. Science (2001) [Pubmed]
Signal transduction. A new thread in an intricate web. von Zastrow, M., Mostov, K. Science (2001) [Pubmed]
Regulation of epidermal growth factor receptor degradation by heterotrimeric Galphas protein. Zheng, B., Lavoie, C., Tang, T.D., Ma, P., Meerloo, T., Beas, A., Farquhar, M.G. Mol. Biol. Cell (2004) [Pubmed]

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