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Gene Review

SCFD1  -  sec1 family domain containing 1

Homo sapiens

Synonyms: C14orf163, FKSG23, KIAA0917, RA410, SLY1, ...
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High impact information on SCFD1

  • In transfected cells, the N-terminal domain of Sly1 specifically disrupts the structure of the Golgi complex, supporting the notion that the interaction of Sly1 with syntaxin 5 is essential for fusion [1].
  • SASH1 is a member of the SH3-domain containing expressed in lymphocytes (SLY1) gene family that encodes signal adapter proteins composed of several protein-protein interaction domains [2].
  • Interestingly in the TCDD/SLY-1 cotreatment study, although synergistic effects on CYP1A1 expression and EROD induction were observed at 4-8h, significant inhibitory effects to TCDD induced CYP1A1 protein and EROD activity were detected at 12-24h of post-treatment [3].
  • The cellular signal transduction system may be modulated following exposure to SLY-1 [3].
  • Thus, photometric analysis of erythroid cells at RA 410 and RA 600 against A 520 seems to provide useful parameters for comparative studies on vertebrate erythroid cells [4].

Anatomical context of SCFD1

  • When the RA values of 410 and 600 nm were compared, it was observed that RA 410 of immature cells was less than that of mature cells (15%), and that immature cells of the lower RA 410 type were present in peripheral blood, as well as in bone marrow of vertebrates [4].

Other interactions of SCFD1

  • In this study, we measured and characterized the bifunctional effects of a newly identified natural compound-bisindigotin (SLY-1), isolated from leaf extracts of Isatis indigotica, to CYP1A1/EROD activities in H4IIE cells [3].


  1. Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Dulubova, I., Yamaguchi, T., Arac, D., Li, H., Huryeva, I., Min, S.W., Rizo, J., Sudhof, T.C. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer. Rimkus, C., Martini, M., Friederichs, J., Rosenberg, R., Doll, D., Siewert, J.R., Holzmann, B., Janssen, K.P. Br. J. Cancer (2006) [Pubmed]
  3. Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells. Lai, K.P., Mak, N.K., Wei, X., Wong, R.N., Wong, M.H., Wong, C.K. Toxicology (2006) [Pubmed]
  4. Comparative cytospectrophotometry of Wright-stained erythroid cells of vertebrates. Kamo, S., Takeuchi, H., Yamada, M. Histol. Histopathol. (1986) [Pubmed]
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