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SASH1  -  SAM and SH3 domain containing 1

Homo sapiens

Synonyms: KIAA0790, PEPE1, Proline-glutamate repeat-containing protein, SAM and SH3 domain-containing protein 1, SH3D6A, ...
 
 
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Disease relevance of SASH1

  • SASH1 is downregulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues [1].
  • We show augmentation of motility associated with morphological changes of human squamous carcinoma SASH1 cells, human peripheral monocytes (hPMs), and murine macrophage-like cell line J774.1 by superoxide stimulation [2].
  • Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer [3].
  • Expression levels of SASH1 were strongly and significantly reduced in colon cancer of UICC stage II, III, and IV, as well as in liver metastases [3].
  • However, SASH1 expression was not significantly deregulated in precancerous adenomas and in earlier stage lesions (UICC I) [3].
 

High impact information on SASH1

 

Biological context of SASH1

 

Anatomical context of SASH1

  • Two SASH1 transcripts of approximately 4.4 and 7.5 kb exist and are predominantly transcribed in the human breast, lung, thyroid, spleen, placenta and thymus [1].
  • SASH1 is a member of the SH3-domain containing expressed in lymphocytes (SLY1) gene family that encodes signal adapter proteins composed of several protein-protein interaction domains [3].
 

Associations of SASH1 with chemical compounds

  • Using a combination of reference tests to assess the accuracy of a diagnostic test by A. Alonzo and M. Pepe, Statistics in Medicine 1999; 18: 2987-3003 [4].
 

Analytical, diagnostic and therapeutic context of SASH1

  • We have used quantitative real-time PCR to investigate the expression of SASH1 in tissue samples from 113 patients with colon carcinoma, and compared the expression with 15 normal colon tissue samples [3].
  • We demonstrate that PEPEP is a very efficient dye for fluorescence confocal microscopy and a valuable alternative to the most frequently used mitochondrial stains [5].

References

  1. SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer. Zeller, C., Hinzmann, B., Seitz, S., Prokoph, H., Burkhard-Goettges, E., Fischer, J., Jandrig, B., Schwarz, L.E., Rosenthal, A., Scherneck, S. Oncogene (2003) [Pubmed]
  2. Essential role of protein kinase C {zeta} in transducing a motility signal induced by superoxide and a chemotactic peptide, fMLP. Kuribayashi, K., Nakamura, K., Tanaka, M., Sato, T., Kato, J., Sasaki, K., Takimoto, R., Kogawa, K., Terui, T., Takayama, T., Onuma, T., Matsunaga, T., Niitsu, Y. J. Cell Biol. (2007) [Pubmed]
  3. Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer. Rimkus, C., Martini, M., Friederichs, J., Rosenberg, R., Doll, D., Siewert, J.R., Holzmann, B., Janssen, K.P. Br. J. Cancer (2006) [Pubmed]
  4. Using a combination of reference tests to assess the accuracy of a diagnostic test by A. Alonzo and M. Pepe, Statistics in Medicine 1999; 18: 2987-3003. Hadgu, A., Miller, W. Statistics in medicine. (2001) [Pubmed]
  5. Novel nontoxic mitochondrial probe for confocal fluorescence microscopy. Versari, S., Villa, A.M., Villa, A., Doglia, S.M., Pagani, G.A., Bradamante, S. Journal of biomedical optics. (2006) [Pubmed]
 
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