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Gene Review

CSTF2T  -  cleavage stimulation factor, 3' pre-RNA,...

Homo sapiens

Synonyms: CF-1 64 kDa subunit tau variant, CSTF 64 kDa subunit tau variant, Cleavage stimulation factor 64 kDa subunit tau variant, Cleavage stimulation factor subunit 2 tau variant, CstF-64T, ...
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Disease relevance of CSTF2T


High impact information on CSTF2T

  • The mouse tauCstF-64 protein fits the criteria of the variant CstF-64, including antibody reactivity, size, germ cell expression, and a common proteolytic digest pattern with tauCstF-64 from testis [2].
  • We have named the variant form "tau CstF-64," and we describe here the cloning and characterization of the mouse tauCstF-64 cDNA, which maps to chromosome 19 [2].
  • Alignment of human tauCstF-64 with human genome sequence from chromosome 10 shows that CSTF2T lacks introns [1].
  • Recent research in our laboratory has uncovered a new form of an essential polyadenylation protein, tauCstF-64, that is most highly expressed in male germ cells, and to a smaller extent in the brain, and which we propose plays a significant role in AAUAAA-independent mRNA polyadenylation in germ cells [3].
  • Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers [4].

Biological context of CSTF2T


Other interactions of CSTF2T

  • We quantified K(d) values of CstF-64 and tauCstF-64 RBDs for various ribopolymers using an RNA cross-linking assay [4].

Analytical, diagnostic and therapeutic context of CSTF2T

  • Radiation hybrid mapping places the human tauCstF-64 gene at 10q22-q23, which is the site of a translocation that has been associated with human neurological problems and male infertility [1].


  1. The gene CSTF2T, encoding the human variant CstF-64 polyadenylation protein tauCstF-64, lacks introns and may be associated with male sterility. Dass, B., McDaniel, L., Schultz, R.A., Attaya, E., MacDonald, C.C. Genomics (2002) [Pubmed]
  2. The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice. Dass, B., McMahon, K.W., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., MacDonald, C.C. J. Biol. Chem. (2001) [Pubmed]
  3. Reexamining the polyadenylation signal: were we wrong about AAUAAA? MacDonald, C.C., Redondo, J.L. Mol. Cell. Endocrinol. (2002) [Pubmed]
  4. Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers. Monarez, R.R., Macdonald, C.C., Dass, B. Biochem. J. (2007) [Pubmed]
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