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Gene Review

TMEM131  -  transmembrane protein 131

Homo sapiens

Synonyms: CC28, KIAA0257, PRO1048, Protein RW1, RW1, ...
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Disease relevance of TMEM131


High impact information on TMEM131

  • DNA strand breaks as measured by comet assay were increased in alveolar macrophages and lung epithelial cells of RW1 and MMVF10 treated rats [2].
  • The potential of two asbestos substitute mineral fibres--rock (stone) wool RW1 and glass wool MMVF10--to induce gene mutations, DNA strand breaks, inflammation and oxidative stress has been studied in rats [2].

Associations of TMEM131 with chemical compounds

  • The results showed that 10mg/L cadmium, mercury and copper not only affected the growth of RW1 with dibenzofuran but also the ability of resting cells to degrade this compound [3].


  1. Biodegradation pathway of 2-chlorodibenzo-p-dioxin and 2-chlorodibenzofuran in the biphenyl-utilising strain JB1. Parsons, J.R., de Bruijne, J.A., Weiland, A.R. Chemosphere (1998) [Pubmed]
  2. Mutagenesis by man-made mineral fibres in the lung of rats. Topinka, J., Loli, P., Dusinská, M., Hurbánková, M., Kováciková, Z., Volkovová, K., Kazimírová, A., Barancoková, M., Tatrai, E., Wolff, T., Oesterle, D., Kyrtopoulos, S.A., Georgiadis, P. Mutat. Res. (2006) [Pubmed]
  3. Effect of heavy metals on the biodegradation of dibenzofuran in liquid medium. Hong, H.B., Nam, I.H., Kim, Y.M., Chang, Y.S., Schmidt, S. J. Hazard. Mater. (2007) [Pubmed]
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