Disease relevance of Kel

• The human Kell blood group system is important in transfusion medicine, since Kell is a polymorphic protein and some of its antigens can cause severe reactions if mismatched blood is transfused, while maternal alloimmunization may lead to fetal and neonatal anemia [1].

High impact information on Kel

• The Kell blood group protein is a zinc endopeptidase that yields endothelin-3, a potent bioactive peptide, by cleavage of big endothelin-3, a larger intermediate precursor [2].
• Kell blood group antigens are part of a 93,000-dalton red cell membrane protein [3].
• Kel was located to proximal Chromosome 6 [1].
• The mouse Kell gene (Kel), like its human counterpart, is similarly organized into 19 exons [1].
• Kx is disulphide bond linked to the Kell glycoprotein, which is a bitopic type II membrane protein carrying the Kell blood group antigen [4].

Associations of Kel with chemical compounds

• Concurrent administration of ranitidine and phenobarbital resulted in an increase in the (Kel) but the change was less than that seen after phenobarbital alone [5].
• No change in antipyrine total elimination rate constant (Kel) was seen after ranitidine administration alone [5].

References