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Gene Review

Lamp3  -  lysosomal-associated membrane protein 3

Mus musculus

Synonyms: 1200002D17Rik, Cd208, DC LAMP, DC-LAMP, DC-lysosome-associated membrane glycoprotein, ...
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Disease relevance of Lamp3

  • Interestingly, human bronchioloalveolar carcinoma tumor cells, which correspond to transformed type II pneumocytes, express DC-LAMP [1].
  • Furthermore, DC-LAMP appears to be a marker of transformed type II pneumocytes as well, an observation that may help the study and the classification of human lung adenocarcinomas [1].

High impact information on Lamp3


  1. CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Salaun, B., de Saint-Vis, B., Pacheco, N., Pacheco, Y., Riesler, A., Isaac, S., Leroux, C., Clair-Moninot, V., Pin, J.J., Griffith, J., Treilleux, I., Goddard, S., Davoust, J., Kleijmeer, M., Lebecque, S. Am. J. Pathol. (2004) [Pubmed]
  2. Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Salaun, B., de Saint-Vis, B., Clair-Moninot, V., Pin, J.J., Barthélemy-Dubois, C., Kissenpfennig, A., Peronne, C., Bates, E., Mattei, M.G., Lebecque, S. Eur. J. Immunol. (2003) [Pubmed]
  3. Differential use of two AP-3-mediated pathways by lysosomal membrane proteins. Ihrke, G., Kyttälä, A., Russell, M.R., Rous, B.A., Luzio, J.P. Traffic (2004) [Pubmed]
  4. Functional regulation of tyrosinase and LAMP gene family of melanogenesis and cell death in immortal murine melanocytes after repeated exposure to ultraviolet B. Ota, A., Park, J.S., Jimbow, K. Br. J. Dermatol. (1998) [Pubmed]
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