The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Lamp1  -  lysosomal-associated membrane protein 1

Mus musculus

Synonyms: 120 kDa lysosomal membrane glycoprotein, AI196048, CD107 antigen-like family member A, CD107a, LAMP-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lamp1


Psychiatry related information on Lamp1

  • These results demonstrate that fusing Id to LAMP1 enhances CD8(+) and CD4(+) Id-specific responses for NHLs and may be useful therapeutically [5].

High impact information on Lamp1


Chemical compound and disease context of Lamp1


Biological context of Lamp1


Anatomical context of Lamp1


Associations of Lamp1 with chemical compounds

  • By using 3H-glucosamine as a marker of N-glycosylation, its incorporation into tyrosinase and LAMP-1 was found to be elevated in hybrids, suppressed by N-glycosylation inhibitors, and stimulated by MSH to a greater degree in hybrids compared to parental cells [4].
  • In these type I and type II granules, MHC class II molecules, mannose-6-phosphate receptors and lysosomal membrane proteins (lamp1 and lamp2) localize to small intralumenal vesicles [21].
  • The increased level and glycosylation of both LAMP-1 and LAMP-2 was observed also in cells treated with a synthetic chalcone carboxylic acid analog of RA and by combination of either retinoid with dibutyryl cyclic AMP [22].
  • There was no increase in large polylactosaminoglycans of lamp-1 and lamp-2 after retinoic acid treatment, but an increase in the size of small polylactosaminoglycans (included on Bio-Gel P-6) and tri- and tetra-antennary complex oligosaccharides [23].
  • In melanocytes treated with U18666A, tyrosinase accumulates in a compartment that contains both lysosome-associated membrane protein-1 (Lamp 1) and MPR, and stains with filipin, consistent with cholesterol-laden late endosomes/lysosomes [24].

Co-localisations of Lamp1


Other interactions of Lamp1


Analytical, diagnostic and therapeutic context of Lamp1


  1. PU.1 Redirects Adenovirus to Lysosomes in Alveolar Macrophages, Uncoupling Internalization from Infection. Carey, B., Staudt, M.K., Bonaminio, D., van der Loo, J.C., Trapnell, B.C. J. Immunol. (2007) [Pubmed]
  2. Lysosomal membranes from beige mice contain higher than normal levels of endoplasmic reticulum proteins. Zhang, H., Fan, X., Bagshaw, R.D., Zhang, L., Mahuran, D.J., Callahan, J.W. J. Proteome Res. (2007) [Pubmed]
  3. Extracellular lysosome-associated membrane protein-1 (LAMP-1) mediates autoimmune disease progression in the NOD model of type 1 diabetes. De Carvalho Bittencourt, M., Herren, S., Graber, P., Vilbois, F., Pasquali, C., Berney, C., Plitz, T., Nicoletti, F., Kosco-Vilbois, M.H. Eur. J. Immunol. (2005) [Pubmed]
  4. Melanoma x macrophage fusion hybrids acquire increased melanogenesis and metastatic potential: altered N-glycosylation as an underlying mechanism. Sodi, S.A., Chakraborty, A.K., Platt, J.T., Kolesnikova, N., Rosemblat, S., Keh-Yen, A., Bolognia, J.L., Rachkovsky, M.L., Orlow, S.J., Pawelek, J.M. Pigment Cell Res. (1998) [Pubmed]
  5. Molecular modification of idiotypes from B-cell lymphomas for expression in mature dendritic cells as a strategy to induce tumor-reactive CD4+ and CD8+ T-cell responses. Muraro, S., Bondanza, A., Bellone, M., Greenberg, P.D., Bonini, C. Blood (2005) [Pubmed]
  6. Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Reddy, A., Caler, E.V., Andrews, N.W. Cell (2001) [Pubmed]
  7. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Sturgill-Koszycki, S., Schlesinger, P.H., Chakraborty, P., Haddix, P.L., Collins, H.L., Fok, A.K., Allen, R.D., Gluck, S.L., Heuser, J., Russell, D.G. Science (1994) [Pubmed]
  8. Processing of Mycobacterium tuberculosis antigen 85B involves intraphagosomal formation of peptide-major histocompatibility complex II complexes and is inhibited by live bacilli that decrease phagosome maturation. Ramachandra, L., Noss, E., Boom, W.H., Harding, C.V. J. Exp. Med. (2001) [Pubmed]
  9. Legionella pneumophila replication vacuoles mature into acidic, endocytic organelles. Sturgill-Koszycki, S., Swanson, M.S. J. Exp. Med. (2000) [Pubmed]
  10. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. Gruenheid, S., Pinner, E., Desjardins, M., Gros, P. J. Exp. Med. (1997) [Pubmed]
  11. Class II MHC molecules are present in macrophage lysosomes and phagolysosomes that function in the phagocytic processing of Listeria monocytogenes for presentation to T cells. Harding, C.V., Geuze, H.J. J. Cell Biol. (1992) [Pubmed]
  12. Bisecting GlcNAc structures act as negative sorting signals for cell surface glycoproteins in forskolin-treated rat hepatoma cells. Sultan, A.S., Miyoshi, E., Ihara, Y., Nishikawa, A., Tsukada, Y., Taniguchi, N. J. Biol. Chem. (1997) [Pubmed]
  13. Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages. Joshi, A.D., Sturgill-Koszycki, S., Swanson, M.S. Cell. Microbiol. (2001) [Pubmed]
  14. A role for synaptotagmin VII-regulated exocytosis of lysosomes in neurite outgrowth from primary sympathetic neurons. Arantes, R.M., Andrews, N.W. J. Neurosci. (2006) [Pubmed]
  15. LAMP proteins are required for fusion of lysosomes with phagosomes. Huynh, K.K., Eskelinen, E.L., Scott, C.C., Malevanets, A., Saftig, P., Grinstein, S. EMBO J. (2007) [Pubmed]
  16. Molecular characterization of P2B/LAMP-1, a major protein target of a metastasis-associated oligosaccharide structure. Heffernan, M., Yousefi, S., Dennis, J.W. Cancer Res. (1989) [Pubmed]
  17. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Eskelinen, E.L., Schmidt, C.K., Neu, S., Willenborg, M., Fuertes, G., Salvador, N., Tanaka, Y., Lüllmann-Rauch, R., Hartmann, D., Heeren, J., von Figura, K., Knecht, E., Saftig, P. Mol. Biol. Cell (2004) [Pubmed]
  18. The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane. Rohrer, J., Schweizer, A., Russell, D., Kornfeld, S. J. Cell Biol. (1996) [Pubmed]
  19. Distribution and dynamics of Lamp1-containing endocytic organelles in fibroblasts deficient in BLOC-3. Falcón-Pérez, J.M., Nazarian, R., Sabatti, C., Dell'Angelica, E.C. J. Cell. Sci. (2005) [Pubmed]
  20. The mouse ocular albinism 1 gene product is an endolysosomal protein. Samaraweera, P., Shen, B., Newton, J.M., Barsh, G.S., Orlow, S.J. Exp. Eye Res. (2001) [Pubmed]
  21. Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Raposo, G., Tenza, D., Mecheri, S., Peronet, R., Bonnerot, C., Desaymard, C. Mol. Biol. Cell (1997) [Pubmed]
  22. Modulation of lysosomal-associated membrane glycoproteins during retinoic acid-induced embryonal carcinoma cell differentiation. Amos, B., Lotan, R. J. Biol. Chem. (1990) [Pubmed]
  23. Lamp-1 does not acquire the large polylactosaminoglycans characteristic of F9 cells. Romero, P.A., Way, T., Herscovics, A. Biochem. J. (1993) [Pubmed]
  24. Accumulation of tyrosinase in the endolysosomal compartment is induced by U18666A. Hall, A.M., Krishnamoorthy, L., Orlow, S.J. Pigment Cell Res. (2003) [Pubmed]
  25. Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice. Denis, C.V., André, P., Saffaripour, S., Wagner, D.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  26. Normal lysosomal morphology and function in LAMP-1-deficient mice. Andrejewski, N., Punnonen, E.L., Guhde, G., Tanaka, Y., Lüllmann-Rauch, R., Hartmann, D., von Figura, K., Saftig, P. J. Biol. Chem. (1999) [Pubmed]
  27. Identification and characterization of a major lysosomal membrane glycoprotein, LGP85/LIMP II in mouse liver. Tabuchi, N., Akasaki, K., Sasaki, T., Kanda, N., Tsuji, H. J. Biochem. (1997) [Pubmed]
  28. t-complex-associated embryonic surface antigen homologous to mLAMP-1. I. Biochemical and molecular analyses. Gray-Bablin, J., Acevedo-Schermerhorn, C., Gama, R., McCormick, P.J. Exp. Cell Res. (1997) [Pubmed]
  29. Kinetics of intracellular transport and sorting of lysosomal membrane and plasma membrane proteins. Green, S.A., Zimmer, K.P., Griffiths, G., Mellman, I. J. Cell Biol. (1987) [Pubmed]
  30. Identification of two lysosomal membrane glycoproteins. Chen, J.W., Murphy, T.L., Willingham, M.C., Pastan, I., August, J.T. J. Cell Biol. (1985) [Pubmed]
WikiGenes - Universities