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Gene Review

LAMP3  -  lysosomal-associated membrane protein 3

Homo sapiens

Synonyms: CD208, DC LAMP, DC-LAMP, DC-lysosome-associated membrane glycoprotein, DCLAMP, ...
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Disease relevance of LAMP3


High impact information on LAMP3


Biological context of LAMP3


Anatomical context of LAMP3


Associations of LAMP3 with chemical compounds

  • Aerobic Oxidation of Benzyl- and Allylic Alcohols under Visible Light Irradiation of a Fluorescent Lamp in the Presence of Catalytic Iodine [12].

Other interactions of LAMP3

  • Immature and mature DCs were defined by the expression of CD1a and DC-LAMP/CD83, respectively [13].
  • It is striking that the LC subset is able to express a high level of CCR7 expression and the maturation marker DC-lysosome-associated membrane protein (DC-LAMP) [14].
  • In addition, neutralization of IL-10 during the differentiation of DCs increased the expression of DC-LAMP and MHC class II by IFN-DCs, and the ability of IFN-DCs to stimulate allogeneic CD4(+) T-cell proliferation at similar levels, than IL-4-DCs [15].
  • DC-LAMP and CC-10 reactivity was also observed in endometrial adenocarcinomas but not in other tumor types [2].
  • Sequential colocalization of an asialoglycoprotein-pulse with rab7 and lamp3 demonstrates that early endosomes change into or fuse with late endosomes and lysosomes [16].

Analytical, diagnostic and therapeutic context of LAMP3


  1. Dendritic cell-lysosomal-associated membrane protein (LAMP) and LAMP-1-HIV-1 gag chimeras have distinct cellular trafficking pathways and prime T and B cell responses to a diverse repertoire of epitopes. Arruda, L.B., Sim, D., Chikhlikar, P.R., Maciel, M., Akasaki, K., August, J.T., Marques, E.T. J. Immunol. (2006) [Pubmed]
  2. DC-LAMP stains pulmonary adenocarcinoma with bronchiolar Clara cell differentiation. Zhu, L.C., Yim, J., Chiriboga, L., Cassai, N.D., Sidhu, G.S., Moreira, A.L. Hum. Pathol. (2007) [Pubmed]
  3. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. de Saint-Vis, B., Vincent, J., Vandenabeele, S., Vanbervliet, B., Pin, J.J., Aït-Yahia, S., Patel, S., Mattei, M.G., Banchereau, J., Zurawski, S., Davoust, J., Caux, C., Lebecque, S. Immunity (1998) [Pubmed]
  4. In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas. Bell, D., Chomarat, P., Broyles, D., Netto, G., Harb, G.M., Lebecque, S., Valladeau, J., Davoust, J., Palucka, K.A., Banchereau, J. J. Exp. Med. (1999) [Pubmed]
  5. Human thymus contains IFN-alpha-producing CD11c(-), myeloid CD11c(+), and mature interdigitating dendritic cells. Bendriss-Vermare, N., Barthélémy, C., Durand, I., Bruand, C., Dezutter-Dambuyant, C., Moulian, N., Berrih-Aknin, S., Caux, C., Trinchieri, G., Brière, F. J. Clin. Invest. (2001) [Pubmed]
  6. Simian immunodeficiency virus dramatically alters expression of homeostatic chemokines and dendritic cell markers during infection in vivo. Choi, Y.K., Fallert, B.A., Murphey-Corb, M.A., Reinhart, T.A. Blood (2003) [Pubmed]
  7. Isolation and characterization of a novel human lung-specific gene homologous to lysosomal membrane glycoproteins 1 and 2: significantly increased expression in cancers of various tissues. Ozaki, K., Nagata, M., Suzuki, M., Fujiwara, T., Ueda, K., Miyoshi, Y., Takahashi, E., Nakamura, Y. Cancer Res. (1998) [Pubmed]
  8. Expression of C-type lectin receptors by subsets of dendritic cells in human skin. Ebner, S., Ehammer, Z., Holzmann, S., Schwingshackl, P., Forstner, M., Stoitzner, P., Huemer, G.M., Fritsch, P., Romani, N. Int. Immunol. (2004) [Pubmed]
  9. The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells. Kobayashi, T., Vischer, U.M., Rosnoblet, C., Lebrand, C., Lindsay, M., Parton, R.G., Kruithof, E.K., Gruenberg, J. Mol. Biol. Cell (2000) [Pubmed]
  10. Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: role of maturation status and intratumoral localization. Sandel, M.H., Dadabayev, A.R., Menon, A.G., Morreau, H., Melief, C.J., Offringa, R., van der Burg, S.H., Janssen-van Rhijn, C.M., Ensink, N.G., Tollenaar, R.A., van de Velde, C.J., Kuppen, P.J. Clin. Cancer Res. (2005) [Pubmed]
  11. Gene induction during differentiation of human pulmonary type II cells in vitro. Wade, K.C., Guttentag, S.H., Gonzales, L.W., Maschhoff, K.L., Gonzales, J., Kolla, V., Singhal, S., Ballard, P.L. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  12. Aerobic Oxidation of Benzyl- and Allylic Alcohols under Visible Light Irradiation of a Fluorescent Lamp in the Presence of Catalytic Iodine. Nakayama, H., Itoh, A. Chem. Pharm. Bull. (2006) [Pubmed]
  13. Anatomic localization of immature and mature dendritic cell subsets in dermatomyositis and polymyositis: Interaction with chemokines and Th1 cytokine-producing cells. Page, G., Chevrel, G., Miossec, P. Arthritis Rheum. (2004) [Pubmed]
  14. Mixed Langerhans cell and interstitial/dermal dendritic cell subsets emanating from monocytes in Th2-mediated inflammatory conditions respond differently to proinflammatory stimuli. Bechetoille, N., André, V., Valladeau, J., Perrier, E., Dezutter-Dambuyant, C. J. Leukoc. Biol. (2006) [Pubmed]
  15. Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4+ T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cells. Carbonneil, C., Saidi, H., Donkova-Petrini, V., Weiss, L. Int. Immunol. (2004) [Pubmed]
  16. Quantitative microscopy reveals 3D organization and kinetics of endocytosis in rat hepatocytes. Marbet, P., Rahner, C., Stieger, B., Landmann, L. Microsc. Res. Tech. (2006) [Pubmed]
  17. Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Schoeters, E., Nuijten, J.M., Van Den Heuvel, R.L., Nelissen, I., Witters, H., Schoeters, G.E., Van Tendeloo, V.F., Berneman, Z.N., Verheyen, G.R. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  18. A new genetic isolate with a unique phenotype of syndromic oculocutaneous albinism: clinical, molecular, and cellular characteristics. Schreyer-Shafir, N., Huizing, M., Anikster, Y., Nusinker, Z., Bejarano-Achache, I., Maftzir, G., Resnik, L., Helip-Wooley, A., Westbroek, W., Gradstein, L., Rosenmann, A., Blumenfeld, A. Hum. Mutat. (2006) [Pubmed]
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