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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Rgs7  -  regulator of G protein signaling 7

Mus musculus

Synonyms: RGS7, Regulator of G-protein signaling 7
 
 
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High impact information on Rgs7

  • Here, we identify R7BP, a novel neuronally expressed protein that binds R7-Gbeta5 complexes and shuttles them between the plasma membrane and nucleus [1].
  • Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family [1].
  • It is hypothesized that the gene encoding the polycystin-binding partner RGS7 is a candidate for the Chr 1 genetic modifier [2].
  • Interestingly, the gene encoding RGS7, a regulator of G protein signaling that binds to polycystin-1, was mapped to the same Chr 1 interval [2].
  • At 2 h after administering the acute opioid, RGS7 mRNA levels in the striatum plus those of RGS9-2 in the striatum and thalamus were increased, whereas RGS9-2 and RGS11 mRNA were reduced in the cortex [3].

References

  1. Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. Drenan, R.M., Doupnik, C.A., Boyle, M.P., Muglia, L.J., Huettner, J.E., Linder, M.E., Blumer, K.J. J. Cell Biol. (2005) [Pubmed]
  2. Quantitative trait loci modulate renal cystic disease severity in the mouse bpk model. Guay-Woodford, L.M., Wright, C.J., Walz, G., Churchill, G.A. J. Am. Soc. Nephrol. (2000) [Pubmed]
  3. Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine. López-Fando, A., Rodríguez-Muñoz, M., Sánchez-Blázquez, P., Garzón, J. Neuropsychopharmacology (2005) [Pubmed]
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