Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Ascl2 - achaete-scute family bHLH transcription...

Rattus norvegicus

Synonyms: Achaete-scute homolog 2, Ash2, Mash-2, Mash2

Küry, P. et al., Miyamoto, T. et al., Scott, I.C. et al.

Küry, Greiner-Petter, Cornely, Jürgens, Müller,

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Disease relevance of Ascl2

We isolated a clone carrying the partial human homolog, ASCL2, from a human genomic phage library using a PCR product for the rat Ascl2-cDNA as a probe [1].

High impact information on Ascl2

Hand1 promotes differentiation of trophoblast giant cells, whereas Mash2 is required for the maintenance of giant cell precursors, and its overexpression prevents giant cell differentiation [2].
Mash2 represents a first candidate for the missing class B bHLH proteins in peripheral nerves [3].
In addition, we provide strong evidence that Mash2 is a negative regulator of Schwann cell proliferation [3].
Here, we demonstrate that Mash2, a basic helix-loop-helix (bHLH) transcription factor previously shown to be crucial for placenta development, is expressed by Schwann cells of adult peripheral nerves [3].

References

Genomic cloning and localization to chromosome 11p15.5 of the human achaete-scute homolog 2 (ASCL2). Miyamoto, T., Jinno, Y., Sasaki, T., Ikeda, Y., Masuzaki, H., Niikawa, N., Ishikawa, M. Cytogenet. Cell Genet. (1996) [Pubmed]
The HAND1 basic helix-loop-helix transcription factor regulates trophoblast differentiation via multiple mechanisms. Scott, I.C., Anson-Cartwright, L., Riley, P., Reda, D., Cross, J.C. Mol. Cell. Biol. (2000) [Pubmed]
Mammalian achaete scute homolog 2 is expressed in the adult sciatic nerve and regulates the expression of Krox24, Mob-1, CXCR4, and p57kip2 in Schwann cells. Küry, P., Greiner-Petter, R., Cornely, C., Jürgens, T., Müller, H.W. J. Neurosci. (2002) [Pubmed]

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