High impact information on Gucy2g

• Based on Northern hybridization, mRNA for GC-G was predominantly expressed in lung, intestine, and skeletal muscle [1].
• That GC-G represents a guanylyl cyclase was confirmed by both transient expression in COS-7 cells and stable expression in H293 cells [1].
• Using the candidate gene approach to potentially define function, the gene for GC-G was mapped to the distal region of mouse chromosome 19 (syntenic with human chromosome 10q), but no human genetic defect has been ascribed to the GC-G locus [1].
• Endogenous cyclic GMP concentrations of transfected or stable cells, however, were much higher than control cells, suggesting an inability of the cells to effectively regulate GC-G cyclase activity [1].
• A novel membrane form of guanylyl cyclase (GC-G) has been identified through the isolation of a full-length cDNA clone; it is predicted to contain an extracellular ligand binding domain, a single transmembrane segment, and intracellular protein kinase-like and cyclase catalytic domains [1].

Biological context of Gucy2g

• A new type soluble guanylyl cyclase, designated as ksGC (kinase-like domain containing soluble guanylyl cyclase), was identified from a kidney cDNA library [2].

Anatomical context of Gucy2g

• GC-B was present in all tissues except stria vascularis, which contained GC-A and traces of GC-E and GC-G [3].

References