Disease relevance of Stria Vascularis

• Hearing loss in MELAS syndrome appears to be due to dysfunction of the cochlea, probably resulting from metabolic failure of the stria vascularis and outer hair cells [1].
• Effects of organic acids on the edema of the stria vascularis induced by furosemide [2].
• Anti-MK immunoreactivity was observed in the stria vascularis, spiral prominence, spiral ganglion, and ganglion nerve fibers [3].
• Breakdown of stria vascularis blood-labyrinth barrier in C3H/lpr autoimmune disease mice [4].
• From the results obtained, the possibility of the responsibility of vanadate for a hypothetical sudden deafness originating in the stria vascularis was discussed [5].

High impact information on Stria Vascularis

• We found that KVLQT1 is expressed in the stria vascularis of mouse inner ear by in situ hybridization [6].
• Of 11 members of the Kir channel family examined with reverse transcription-PCR, we could detect only expression of KAB-2 (Kir4.1) mRNA in stria vascularis [7].
• EP is generated by the high throughput of K(+) across cells of the stria vascularis, conferred partly by the activity of Kir4.1 channels [8].
• Interruption of this recirculation, which may be caused by the mutation in connexin 26 gene, would deprive the stria vascularis of K(+) and result in hearing loss [9].
• Because TJs of basal cells are primarily composed of claudin-11, claudin-11-deficient (Cld11-/-) mice were generated with an expectation that the compartmentalization in stria vascularis in these mice would be affected [10].

Chemical compound and disease context of Stria Vascularis

• The comparable efficacy of prednisolone and aldosterone in restoring auditory function suggests steroid reversal of autoimmune hearing loss in mice is due to increasing stria vascularis sodium transport and not suppression of systemic autoimmune reactions [11].
• Degeneration of the stria vascularis (SV) is amongst the major causes of cisplatin (CDDP)-induced hearing impairment [12].
• Intercellular edema was observed both in stria vascularis and in endolymphatic sac by light and electronmicroscopy after ethacrynic acid administration [13].
• After administration of mannitol, an osmotic diuretic, edema of the stria vascularis occurs, which is morphologically indistinguishable from the stria edema observed after administration of loop-inhibiting diuretics [14].
• In addition to this, it could be presumable that cyclic AMP in the stria vascularis may increase by the sympathetic stimulation during hypoxemia, and increased cyclic AMP may produce more EP with a given O2 consumption [15].

Biological context of Stria Vascularis

• The beta2 isozyme was present in border, inner phalangeal and Hensen cells, the stria vascularis, and suprastrial and supralimbal fibrocytes where it also may be involved in regulating ion transport activities [16].
• These results suggest that some fibrocytes possessing both the CLC-KB and the NKCC may be involved in the regulation of cell volume, transport and recycling of Cl- such as is seen in the stria vascularis [17].
• Adenylate energy charge, energy status, and phosphorylation state of stria vascularis under metabolic stress [18].
• Because aldosterone regulates sodium, potassium, and other electrolyte homeostasis, this implied the restoration of hearing with the mineralocorticoid was due to its impact on cochlear ion transport, particularly in the stria vascularis [19].
• The presence of DNA fragmentation revealed by a terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labelling method was recognized in the organ of Corti, the spiral ganglion, and the stria vascularis in the cisplatin-treated animals whereas almost negative results were obtained in the control animals [20].

Anatomical context of Stria Vascularis

• Cholesterol distribution in cells of the stria vascularis of the mammalian cochlea and some effects of ototoxic diuretics [21].
• Lack of Pax2 affects tissue specification within the cochlear duct, particularly regions between the sensory tissue and the stria vascularis [22].
• Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea [23].
• The results show that melatonin is detectable in the organ of Corti and the basilar membrane, and to a lesser degree also in the cochlear nerve and stria vascularis, including the spiral ligament [24].
• Cisplatin ototoxicity involves organ of Corti, stria vascularis and spiral ganglion: modulation by alphaMSH and ORG 2766 [25].

Associations of Stria Vascularis with chemical compounds

• Because EP was depressed by vascular perfusion of Ba2+, an inhibitor of inwardly rectifying K+ (Kir) channels, but not by either 4-aminopyridine or tetraethylammonium, we examined the expression of Kir channel subunits in cochlear stria vascularis, the tissue that is supposed to play the central role in the generation of positive EP [7].
• The phospholipase C-gamma isozymes were expressed in supporting cells, the stria vascularis, and certain fibrocytes where they possibly participate in activating tyrosine kinase and modulating ion conductances [16].
• A tubulo-cisternal endoplasmic reticulum system in the potassium transporting marginal cells of the stria vascularis and effects of the ototoxic diuretic ethacrynic acid [26].
• In the stria vascularis, gold particles were sparse over the endolymphatic luminal surface of the marginal cells but were numerous over the basolateral membrane [27].
• The application of 1 mM ouabain and removal of external K+ caused a most striking increase in [Na+]i of the suprastrial fibrocytes, followed by the stria vascularis and the type II fibrocytes, but no detectable response in the type I fibrocytes [28].

Gene context of Stria Vascularis

• A transitory expression of Gjb1 was found in the basal and intermediate cells of the stria vascularis [29].
• From the 12th postnatal day, some scattered intermediate cells started to express S100A6 protein in the stria vascularis [30].
• AQP5 expression continued through postnatal periods with a change of expression domain to the stria vascularis between postnatal day 7 (P7) and P14 [31].
• Endolymphatic duct and sac and stria vascularis expression of Aqp2 was noted to occur fairly late during development but demonstrated a distinct pattern of immunolabeling [32].
• Trk A was not observed in stria vascularis, hair cell stereocilia, nor in the Trk B- and Trk C-rich cerebellum [33].

Analytical, diagnostic and therapeutic context of Stria Vascularis

• We also show that Cx29 mRNA is present in spiral limbus, spiral ligament, organ of Corti, stria vascularis, and lateral wall by the method of RT-PCR [34].
• The purpose of this study was to determine the effects of an intravenous injection of a hyperosmotic agent (mannitol) on the volume density (Vv) of the primary components of the stria vascularis (SV) [35].
• The present study presents animal experiments on the toxic effects of cisplatin in the stria vascularis and in the organ of Corti [36].
• Here, we demonstrate the expression of both known isoforms of ClC-K in the organ of Corti, spiral ligament and stria vascularis of the rat cochlea by immunohistochemical, Western blot and RT-PCR analysis [37].
• The stria vascularis of young albino guinea pigs was examined by scanning electron microscopy at intervals of 30, 60, and 240 minutes after the intracardiac administration of ethacrynic acid (70 mg/kg) [38].

References