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Gene Review

RT1-C  -  RT1 region, class Ib, nonclassical

Rattus norvegicus

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High impact information on RT1-C

  • Previous studies of the rapid rejection of MHC-disparate lymphocytes in rats, named allogeneic lymphocyte cytotoxicity, have indicated that rat NK cells express activating receptors for nonclassical MHC class I allodeterminants from the RT1-C/E/M region [1].
  • However, the mode of rat NK-cell recognition of target cells indicates that positive recognition of allo-MHC determinants, especially those encoded by the RT1-C/E/M region, is a prevalent feature [2].
  • Four previously known microsatellite markers were fine mapped in the RT1-C/E/M region and found to occur in multiple copies [3].
  • We have cloned the telomeric class I region of the RT1 complex, RT1-C/E/M, of the BN inbred rat strain in a contig of overlapping P1-derived artificial chromosome clones encompassing approximately 2 Mb, and present a physical map of this MHC region [3].
  • The class Ia molecules are encoded by the RT1-A region of the rat MHC, while the RT1-C/E/M region encodes up to 60 other class I genes or gene fragments, a number of which are known to be expressed (or to be expressible) [4].

Biological context of RT1-C

  • The relative number of STOK2+ NK cells was fivefold higher in rats expressing the RT1-C/E/M(av1) as compared with those expressing the RT1-C/E/M(u) class Ib haplotype [5].
  • The properties of this region appear similar to the previously described RT1C and the putative genotypes of the PVG X R19 and PVG X R20 congenic lines are therefore AaIaCc and AcIcCa, respectively [6].

Other interactions of RT1-C

  • In conjunction with previous breeding studies, this study maps the diabetes susceptibility gene to the right of the RT1-A locus and to the left of the RT1-C locus [7].


  1. Ly-49s3 is a promiscuous activating rat NK cell receptor for nonclassical MHC class I-encoded target ligands. Naper, C., Hayashi, S., Kveberg, L., Niemi, E.C., Lanier, L.L., Vaage, J.T., Ryan, J.C. J. Immunol. (2002) [Pubmed]
  2. Rat natural killer cell receptor systems and recognition of MHC class I molecules. Rolstad, B., Naper, C., Løvik, G., Vaage, J.T., Ryan, J.C., Bäckman-Petersson, E., Kirsch, R.D., Butcher, G.W. Immunol. Rev. (2001) [Pubmed]
  3. Physical map and expression profile of genes of the telomeric class I gene region of the rat MHC. Ioannidu, S., Walter, L., Dressel, R., Günther, E. J. Immunol. (2001) [Pubmed]
  4. RT1-U: identification of a novel, active, class Ib alloantigen of the rat MHC. Leong, L.Y., Le Rolle, A.F., Deverson, E.V., Powis, S.J., Larkins, A.P., Vaage, J.T., Stokland, A., Lambracht-Washington, D., Rolstad, B., Joly, E., Butcher, G.W. J. Immunol. (1999) [Pubmed]
  5. Genes in two major histocompatibility complex class I regions control selection, phenotype, and function of a rat Ly-49 natural killer cell subset. Naper, C., Ryan, J.C., Kirsch, R., Butcher, G.W., Rolstad, B., Vaage, J.T. Eur. J. Immunol. (1999) [Pubmed]
  6. The new recombinant haplotypes r19 and r20 in RT1, the MHC of the rat. Stephenson, S.P., Butcher, G.W. Transplantation (1984) [Pubmed]
  7. Association of susceptibility to spontaneous diabetes in rat with genes of major histocompatibility complex. Colle, E., Ono, S.J., Fuks, A., Guttmann, R.D., Seemayer, T.A. Diabetes (1988) [Pubmed]
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