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Gene Review

Pgam2  -  phosphoglycerate mutase 2 (muscle)

Rattus norvegicus

Synonyms: BPG-dependent PGAM 2, D14Mgh1, Muscle-specific phosphoglycerate mutase, PGAM-M, Pgmut, ...
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High impact information on Pgam2

  • We have studied the effect of p53 on the expression mediated by the promoter of the rat muscle-specific phosphoglycerate mutase gene (M-PGAM), a marker for cardiac and skeletal muscle differentiation [1].
  • The expression of the gene encoding the muscle-specific (M)-subunit of phosphoglycerate mutase (PGAM-M) is restricted to adult skeletal and cardiac muscle [2].
  • Rat PGAM-M spans about 2.2 kb and is composed of three exons: 442, 181 and 186-bp long, and two introns of 97 bp and 1.3 bp [2].
  • In non-differentiating satellite cells only PGAM-B mRNA was detected, but when cells were differentiated into myotubes, which undergo spontaneous contraction, mRNA for PGAM-M muscle-specific isozyme was also detected [3].
  • The muscle-specific phosphoglycerate mutase gene is specifically expressed in testis during spermatogenesis [4].

Biological context of Pgam2

  • Thus, the muscle-specific PGAM-M gene constitutes a meiotic gene and therefore represents a very interesting model to study differential tissue-specific gene expression [4].

Anatomical context of Pgam2


Analytical, diagnostic and therapeutic context of Pgam2


  1. p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression. Ruiz-Lozano, P., Hixon, M.L., Wagner, M.W., Flores, A.I., Ikawa, S., Baldwin, A.S., Chien, K.R., Gualberto, A. Cell Growth Differ. (1999) [Pubmed]
  2. The gene encoding rat phosphoglycerate mutase subunit M: cloning and promoter analysis in skeletal muscle cells. Ruiz-Lozano, P., de Lecea, L., Buesa, C., Pérez de la Osa, P., LePage, D., Gualberto, A., Walsh, K., Pons, G. Gene (1994) [Pubmed]
  3. Expression of phosphoglycerate mutase mRNA in differentiating rat satellite cell cultures. Castellà-Escolà, J., Ureña, J., Alterio, J., Carreras, J., Martelly, I., Climent, F. FEBS Lett. (1990) [Pubmed]
  4. The muscle-specific phosphoglycerate mutase gene is specifically expressed in testis during spermatogenesis. Broceño, C., Ruiz, P., Reina, M., Vilaró, S., Pons, G. Eur. J. Biochem. (1995) [Pubmed]
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