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Gene Review

AAT2  -  Aortic aneurysm, familial thoracic 2

Homo sapiens

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High impact information on AAT2

  • The AAT2 gene contains 11 exons, with 5 introns located in positions identical to those found in animal AAT genes, and encodes a plastid-localized isozyme [1].
  • The amino acid sequence of the bean PvAAT-2 showed high similarity with the AAT-2 isoforms described in other leguminous plants [2].
  • This report describes the analysis of a transgenic alfalfa (Medicago sativa L.) line containing an antisense NADH-GOGAT (EC under the control of the nodule-enhanced aspartate amino-transferase (AAT-2) promoter [3].
  • This clone was used as a hybridization probe to screen cDNA libraries for additional AAT2 cDNAs [4].
  • The presence or absence of this ten amino acid sequence has no effect on the size or charge of the mature AAT2 protein because it is located within the region encoding the protein's transit peptide, which is proteolytically removed upon transport into plastids [4].

Biological context of AAT2


Associations of AAT2 with chemical compounds

  • AAT-2 uses 2-amino-4-methoxy-4-oxobutanoic acid at a similar rate as L-aspartate but AAT-1 uses this substrate at a slower rate [7].

Other interactions of AAT2

  • These up-regulated genes were ADP/ATP translocase (AAT2), Na(+)/K(+) ATPase, acyloxyacyl hydrolase (AOAH), and platelet-derived growth factor (PDFG-A) [5].


  1. Genomic structure, expression and evolution of the alfalfa aspartate aminotransferase genes. Gregerson, R.G., Miller, S.S., Petrowski, M., Gantt, J.S., Vance, C.P. Plant Mol. Biol. (1994) [Pubmed]
  2. Molecular cloning of the cDNA encoding aspartate aminotransferase from bean root nodules and determination of its role in nodule nitrogen metabolism. Silvente, S., Camas, A., Lara, M. J. Exp. Bot. (2003) [Pubmed]
  3. Decreased NADH glutamate synthase activity in nodules and flowers of alfalfa (Medicago sativa L.) transformed with an antisense glutamate synthase transgene. Schoenbeck, M.A., Temple, S.J., Trepp, G.B., Blumenthal, J.M., Samac, D.A., Gantt, J.S., Hernandez, G., Vance, C.P. J. Exp. Bot. (2000) [Pubmed]
  4. Molecular analysis of allelic polymorphism at the AAT2 locus of alfalfa. Gregerson, R.G., Petrowski, M., Larson, R.L., Gantt, J.S., Vance, C.P. Mol. Gen. Genet. (1993) [Pubmed]
  5. Use of human cDNA microarrays for identification of differentially expressed genes in Atlantic salmon liver during Aeromonas salmonicida infection. Tsoi, S.C., Cale, J.M., Bird, I.M., Ewart, V., Brown, L.L., Douglas, S. Mar. Biotechnol. (2003) [Pubmed]
  6. Genetic variation in the hooded seal, Cystophora cristata, based on enzyme polymorphism and multi-locus DNA fingerprinting. Sundt, R.C., Dahle, G., Naevdal, G. Hereditas (1994) [Pubmed]
  7. Effects of substrate structural analogues on the enzymatic activities of aspartate aminotransferase isoenzymes. Martins, L.L., Mourato, M.P., de Varennes, A. J. Enzym. Inhib. (2001) [Pubmed]
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