Disease relevance of Aldh3a1

• Expression of tumor-associated aldehyde dehydrogenase gene in rat hepatoma cell lines [1].

High impact information on Aldh3a1

• Cloning and complete nucleotide sequence of a full-length cDNA encoding a catalytically functional tumor-associated aldehyde dehydrogenase [2].
• An aldehyde dehydrogenase (ALDH) with properties identical to those of the NADP+-dependent, tumor-associated aldehyde dehydrogenase appearing during rat hepatocarcinogenesis has been identified in normal rat urinary bladder [3].
• The observation that normal urinary bladder possesses an enzyme activity very similar to one expressed during hepatocarcinogenesis, but not in normal liver, is consistent with the hypothesis that derepression of a gene normally repressed in liver is responsible for expression of the tumor-associated aldehyde dehydrogenase phenotype [3].
• Like the tumor-associated aldehyde dehydrogenase, bladder NADP+-ALDH is cytosolic and preferentially oxidizes benzaldehyde-like aromatic aldehydes [3].
• Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP) [4].

Anatomical context of Aldh3a1

• Expression of tumor-associated aldehyde dehydrogenase during rat hepatocarcinogenesis using the resistant hepatocyte model [5].
• During hepatocarcinogenesis, an additional tumor-associated aldehyde dehydrogenase (T-ALDH) is detectable in the cytosol of preneoplastic and neoplastic cells [6].

Associations of Aldh3a1 with chemical compounds

• The tumor-associated aldehyde dehydrogenase 3 (ALDH3) and the glutathione transferase (GST)Ya form are coded by members of the Ah (aryl hydrocarbon) battery group of genes activated in the liver by polycyclic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [7].
• The substrate and coenzyme specificity, immunochemical properties, effect of disulfiram, pH profile, and isoelectric point of cornea aldehyde dehydrogenase are identical to those of tumor-associated aldehyde dehydrogenase, the prototype class 3 enzyme [8].

References