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Gene Review

Aldh3a1  -  aldehyde dehydrogenase family 3, subfamily A1

Mus musculus

Synonyms: Ahd-4, Ahd4, Aldehyde dehydrogenase 4, Aldehyde dehydrogenase family 3 member A1, Aldehyde dehydrogenase, dimeric NADP-preferring, ...
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Disease relevance of Aldh3a1


High impact information on Aldh3a1


Biological context of Aldh3a1

  • Southern hybridization analysis of mouse DNA probed with the full-length cDNA reveals that the Ahd-4 gene is likely to span less than a total of 15 kb, and was mapped to chromosome (Chr) 11 between the Mgat-1 and Shbg loci by analysis of two multilocus crosses [2].
  • In conclusion, we expect one or more putative electrophile response elements (EpRE), previously found in the regulatory regions of the murine Nmol, Ahd4, and ugt1*06 genes, to be functional in responding to phenolic antioxidants [3].
  • The phenotypes were inherited in a normal mendelian fashion, with two alleles at a single locus (Ahd-4) showing codominant expression [4].
  • Recombination studies have indicated, however, that Ahd-4 and Ahd-6 are distinct but closely linked loci on the mouse genome [5].
  • Genetics of ocular NAD+-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse: evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler [4].

Regulatory relationships of Aldh3a1

  • The results thus suggest that Aldh-3 gene is regulated by a mechanism independent of the Ah receptor [6].

Other interactions of Aldh3a1

  • DHII treatment of wt cells for 12 hr markedly elevated the enzyme activities and mRNA levels of genes in the [Ah] battery: aryl hydrocarbon hydroxylase (Cyp1a1), NAD(P)H:menadione oxidoreductase (Nmol), cytosolic aldehyde dehydrogenase class 3 (Ahd4), and UDP-glucuronosyltransferase form 1*06 (Ugt1*06) [3].
  • We have studied three Phase II genes in the mouse dioxin-inducible [Ah] battery: Nmo1 [encoding NAD(P)H:menadione oxidoreductase], Ahd4 (encoding the cytosolic aldehyde dehydrogenase ALDH3c), and Ugt1*06 (a UDP glucuronosyltransferase) [7].
  • The mouse Ahd3 gene is very tightly linked to the Ahd4 gene on chromosome 11 [8].


  1. Mouse cytosolic class 3 aldehyde dehydrogenase (Aldh3a1): gene structure and regulation of constitutive and dioxin-inducible expression. Vasiliou, V., Reuter, S.F., Williams, S., Puga, A., Nebert, D.W. Pharmacogenetics (1999) [Pubmed]
  2. Mouse dioxin-inducible cytosolic aldehyde dehydrogenase-3: AHD4 cDNA sequence, genetic mapping, and differences in mRNA levels. Vasiliou, V., Reuter, S.F., Kozak, C.A., Nebert, D.W. Pharmacogenetics (1993) [Pubmed]
  3. Response of [Ah] battery genes to compounds that protect against menadione toxicity. Vasiliou, V., Shertzer, H.G., Liu, R.M., Sainsbury, M., Nebert, D.W. Biochem. Pharmacol. (1995) [Pubmed]
  4. Genetics of ocular NAD+-dependent alcohol dehydrogenase and aldehyde dehydrogenase in the mouse: evidence for genetic identity with stomach isozymes and localization of Ahd-4 on chromosome 11 near trembler. Holmes, R.S., Popp, R.A., VandeBerg, J.L. Biochem. Genet. (1988) [Pubmed]
  5. Biochemical genetics of aldehyde dehydrogenase isozymes in the mouse: evidence for stomach- and testis-specific isozymes. Mather, P.B., Holmes, R.S. Biochem. Genet. (1984) [Pubmed]
  6. Comparison of expression of aldehyde dehydrogenase 3 and CYP1A1 in dominant and recessive aryl hydrocarbon hydroxylase-deficient mutant mouse hepatoma cells. Korkalainen, M.K., Törrönen, A.R., Kärenlampi, S.O. Chem. Biol. Interact. (1995) [Pubmed]
  7. Interaction between the Ah receptor and proteins binding to the AP-1-like electrophile response element (EpRE) during murine phase II [Ah] battery gene expression. Vasiliou, V., Puga, A., Chang, C.Y., Tabor, M.W., Nebert, D.W. Biochem. Pharmacol. (1995) [Pubmed]
  8. Mouse microsomal Class 3 aldehyde dehydrogenase: AHD3 cDNA sequence, inducibility by dioxin and clofibrate, and genetic mapping. Vasiliou, V., Kozak, C.A., Lindahl, R., Nebert, D.W. DNA Cell Biol. (1996) [Pubmed]
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