Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

cdc23 - MCM-associated protein Mcm10

Schizosaccharomyces pombe 972h-

Aves, S.J. et al., Hart, E.A. et al., Locovei, A.M. et al.

Locovei, Spiga, Tanaka, Murakami, D'Urso, Aves, Tongue, Foster, Hart,

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High impact information on cdc23

The wild-type cdc23 gene on multicopy plasmids can partially suppress temperature-dependent defects in mcm5 (nda4-108) [1].
These structural and functional homologies between two distantly related species suggest that cdc23 and DNA43 may represent genes for a conserved essential eukaryotic DNA replication function [2].
We have cloned the Schizosaccharomyces pombe cdc23 gene by complementation of the temperature-sensitive phenotype of cdc23-M36 and confirmed the identity of the gene by integrative mapping [2].
The fission yeast cdc23 gene is required for correct DNA replication: cdc23 mutants show reduced rates of DNA synthesis and become elongated after cell-cycle arrest [2].

Biological context of cdc23

The S. pombe cdc23 gene on an expression plasmid is able to complement the S. cerevisiae dna43-1 mutant [2].

Analytical, diagnostic and therapeutic context of cdc23

Here we show that Abp1 interacts with the DNA replication protein Cdc23 (MCM10) in a two-hybrid assay, and that the Deltaabp1 mutant displays a synthetic phenotype with a cdc23 temperature-sensitive mutant [3].

References

Fission yeast Cdc23 interactions with DNA replication initiation proteins. Hart, E.A., Bryant, J.A., Moore, K., Aves, S.J. Curr. Genet. (2002) [Pubmed]
The essential schizosaccharomyces pombe cdc23 DNA replication gene shares structural and functional homology with the Saccharomyces cerevisiae DNA43 (MCM10) gene. Aves, S.J., Tongue, N., Foster, A.J., Hart, E.A. Curr. Genet. (1998) [Pubmed]
The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast. Locovei, A.M., Spiga, M.G., Tanaka, K., Murakami, Y., D'Urso, G. Cell division (2006) [Pubmed]

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