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PP2A-1  -  serine/threonine-protein phosphatase PP2A...

Arabidopsis thaliana

Synonyms: F23H11.15, F23H11_15, protein phosphatase 2A-1, protein phosphatase 2A-2
 
 
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High impact information on PP2A-1

  • The heterotrimeric protein phosphatase 2A (PP2A) complex comprises a catalytic subunit and regulatory A and B subunits that modulate enzyme activity and mediate interactions with other proteins [1].
  • A guard cell-expressed PP2A gene, RCN1, which had been characterized previously as a molecular component affecting auxin transport and gravity response, was isolated [2].
  • Pharmacological studies have led to a model in which the phytohormone abscisic acid (ABA) may be positively transduced via protein phosphatases of the type 1 (PP1) or type 2A (PP2A) families [2].
  • Since PP2A was previously shown to be involved in low-temperature responses in plants, the low-temperature-sensitive phenotype observed in AtCHIP-overexpressing plants might be partly due to the change in PP2A activity [3].
  • The PP2Ac-silenced plants had greatly decreased PP2A activity, constitutively expressed pathogenesis-related (PR) genes, and developed localized cell death in stems and leaves [4].
 

Biological context of PP2A-1

  • Type 2A serine/threonine protein phosphatases (PP2A) are important components in the reversible protein phosphorylation events in plants and other organisms [5].
  • The analysis of the complete genome of Arabidopsis allowed us to characterize four novel genes, AtB'epsilon, AtB'zeta, AtB'eta, and AtB'theta;, belonging to the PP2A B' regulatory subunit family [5].
  • Type 2A serine/threonine protein phosphatases (PP2A) are key components in the regulation of signal transduction and control of cell metabolism [6].
  • In addition, other plant species also contain DNA sequences homologous to the B regulatory subunit, indicating that regulation of PP2A activity by the 55 kDa B regulatory subunit is probably ubiquitous in plants [6].
 

Associations of PP2A-1 with chemical compounds

 

Other interactions of PP2A-1

 

Analytical, diagnostic and therapeutic context of PP2A-1

References

  1. Disparate roles for the regulatory A subunit isoforms in Arabidopsis protein phosphatase 2A. Zhou, H.W., Nussbaumer, C., Chao, Y., DeLong, A. Plant Cell (2004) [Pubmed]
  2. Disruption of a guard cell-expressed protein phosphatase 2A regulatory subunit, RCN1, confers abscisic acid insensitivity in Arabidopsis. Kwak, J.M., Moon, J.H., Murata, Y., Kuchitsu, K., Leonhardt, N., DeLong, A., Schroeder, J.I. Plant Cell (2002) [Pubmed]
  3. AtCHIP functions as an E3 ubiquitin ligase of protein phosphatase 2A subunits and alters plant response to abscisic acid treatment. Luo, J., Shen, G., Yan, J., He, C., Zhang, H. Plant J. (2006) [Pubmed]
  4. Silencing of subfamily I of protein phosphatase 2A catalytic subunits results in activation of plant defense responses and localized cell death. He, X., Anderson, J.C., del Pozo, O., Gu, Y.Q., Tang, X., Martin, G.B. Plant J. (2004) [Pubmed]
  5. Molecular characterization and evolution of the protein phosphatase 2A B' regulatory subunit family in plants. Terol, J., Bargues, M., Carrasco, P., Pérez-Alonso, M., Paricio, N. Plant Physiol. (2002) [Pubmed]
  6. Characterization of a cDNA encoding the 55 kDa B regulatory subunit of Arabidopsis protein phosphatase 2A. Rundle, S.J., Hartung, A.J., Corum, J.W., O'Neill, M. Plant Mol. Biol. (1995) [Pubmed]
  7. The Arabidopsis homolog of yeast TAP42 and mammalian alpha4 binds to the catalytic subunit of protein phosphatase 2A and is induced by chilling. Harris, D.M., Myrick, T.L., Rundle, S.J. Plant Physiol. (1999) [Pubmed]
  8. Enhanced ethylene responsiveness in the Arabidopsis eer1 mutant results from a loss-of-function mutation in the protein phosphatase 2A A regulatory subunit, RCN1. Larsen, P.B., Cancel, J.D. Plant J. (2003) [Pubmed]
  9. Differential expression of three Arabidopsis genes encoding the B' regulatory subunit of protein phosphatase 2A. Latorre, K.A., Harris, D.M., Rundle, S.J. Eur. J. Biochem. (1997) [Pubmed]
  10. Mutations in a new Arabidopsis cyclophilin disrupt its interaction with protein phosphatase 2A. Jackson, K., Söll, D. Mol. Gen. Genet. (1999) [Pubmed]
  11. Protein phosphatases in higher plants: multiplicity of type 2A phosphatases in Arabidopsis thaliana. Ariño, J., Pérez-Callejón, E., Cunillera, N., Camps, M., Posas, F., Ferrer, A. Plant Mol. Biol. (1993) [Pubmed]
 
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