The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

mik1  -  mitotic inhibitor kinase Mik1

Schizosaccharomyces pombe 972h-

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on mik1


Biological context of mik1

  • Here we focus on the evidence from yeast genetics that the wee1 and mik1 tyrosine kinases cooperate in the inhibitory phosphorylation of cdc2p, and the possibility that these kinases function in pathways that ensure the integrity of the genome prior to cell division [5].
  • Because of the functional conservation of cell cycle control elements, the expression of a vertebrate wee1 or mik1 homolog would be expected to rescue such lethal mutations in yeast [4].
  • Finally, we discuss the genes involved in these feedback controls and suggest that wee1p and mik1p might be the ultimate effectors that prevent mitosis when a checkpoint is triggered [5].


  1. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Lundgren, K., Walworth, N., Booher, R., Dembski, M., Kirschner, M., Beach, D. Cell (1991) [Pubmed]
  2. Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. Kornbluth, S., Sebastian, B., Hunter, T., Newport, J. Mol. Biol. Cell (1994) [Pubmed]
  3. Cdc18p can block mitosis by two independent mechanisms. Greenwood, E., Nishitani, H., Nurse, P. J. Cell. Sci. (1998) [Pubmed]
  4. Cloning and expression of a Xenopus gene that prevents mitotic catastrophe in fission yeast. Su, J.Y., Maller, J.L. Mol. Gen. Genet. (1995) [Pubmed]
  5. Tyrosine kinases wee1 and mik1 as effectors of DNA replication checkpoint control. Tourret, J., McKeon, F. Progress in cell cycle research. (1996) [Pubmed]
WikiGenes - Universities