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Gene Review:

gyp1 - GTPase activating protein Gyp1 (predicted)

Schizosaccharomyces pombe 972h-

Cuif, M.H. et al., Haberland, J. et al., Matynia, A. et al., Fournier, N. et al., Imai, Y. et al.

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High impact information on SPBC530.01

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome [1].
Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences [2].
The small GTP binding protein Ran is an essential component of the nuclear protein import machinery whose GTPase cycle is regulated by the nuclear guanosine nucleotide exchange factor RCC1 and by the cytosolic GTPase activating protein RanGAP [3].
This is negatively regulated by the two-component GTPase-activating protein (GAP) comprised of the products of the cdc16 and byr4 genes [4].

Analytical, diagnostic and therapeutic context of SPBC530.01

Sequence analysis of gap1 indicates that it encodes a homolog of the mammalian Ras GTPase-activating protein (GAP) [5].

References

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome. Cuif, M.H., Possmayer, F., Zander, H., Bordes, N., Jollivet, F., Couedel-Courteille, A., Janoueix-Lerosey, I., Langsley, G., Bornens, M., Goud, B. EMBO J. (1999) [Pubmed]
Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences. Matynia, A., Dimitrov, K., Mueller, U., He, X., Sazer, S. Mol. Cell. Biol. (1996) [Pubmed]
The acidic C-terminal domain of rna1p is required for the binding of Ran.GTP and for RanGAP activity. Haberland, J., Becker, J., Gerke, V. J. Biol. Chem. (1997) [Pubmed]
Bypass of the requirement for cdc16p GAP function in Schizosaccharomyces pombe by mutation of the septation initiation network genes. Fournier, N., Cerutti, L., Beltraminelli, N., Salimova, E., Simanis, V. Arch. Microbiol. (2001) [Pubmed]
Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe. Imai, Y., Miyake, S., Hughes, D.A., Yamamoto, M. Mol. Cell. Biol. (1991) [Pubmed]

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