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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

spi1  -  Ran GTPase Spi1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on spi1

  • We show that the tomato Ran protein can suppress the Sch. pombe pim1 mutation, indicating that the tomato Ran protein and the Sch. pombe spi1 protein are functionally homologous [1].
  • A loss of pim1p GEF activity or an increase in the rna1p GAP activity correlates with a change in the localization of the GTPase from predominantly nuclear to uniformly distributed, suggesting that the two forms are topologically segregated and that the nucleotide-bound state of spi1p may dictate its intracellular localization [2].
  • Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences [2].
 

Other interactions of spi1

  • Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase [3].

References

  1. A small nuclear GTP-binding protein from tomato suppresses a Schizosaccharomyces pombe cell-cycle mutant. Ach, R.A., Gruissem, W. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences. Matynia, A., Dimitrov, K., Mueller, U., He, X., Sazer, S. Mol. Cell. Biol. (1996) [Pubmed]
  3. Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase. Matsumoto, T., Beach, D. Mol. Biol. Cell (1993) [Pubmed]
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