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Gene Review

spi1  -  Ran GTPase Spi1

Schizosaccharomyces pombe 972h-

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High impact information on spi1

  • We show that the tomato Ran protein can suppress the Sch. pombe pim1 mutation, indicating that the tomato Ran protein and the Sch. pombe spi1 protein are functionally homologous [1].
  • A loss of pim1p GEF activity or an increase in the rna1p GAP activity correlates with a change in the localization of the GTPase from predominantly nuclear to uniformly distributed, suggesting that the two forms are topologically segregated and that the nucleotide-bound state of spi1p may dictate its intracellular localization [2].
  • Perturbations in the spi1p GTPase cycle of Schizosaccharomyces pombe through its GTPase-activating protein and guanine nucleotide exchange factor components result in similar phenotypic consequences [2].

Other interactions of spi1

  • Interaction of the pim1/spi1 mitotic checkpoint with a protein phosphatase [3].


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