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Gene Review:

trz2 - mitochondrial 3'-tRNA processing...

Schizosaccharomyces pombe 972h-

Papadimou, E. et al., Zimmerly, S. et al., Macrae, I.J. et al., Murakami, H. et al., Mann, W. et al., et al.

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High impact information on SPBC3D6.03c

RDRC physically interacts with RITS in a manner that requires the Dicer ribonuclease (Dcr1) and the Clr4 histone methyltransferase [1].
Additive inhibitory effect of calcipotriol and anthralin on ribonuclease P activity [2].
The effects of two antipsoriatic compounds, calcipotriol and anthralin, separately or in combination on ribonuclease P (RNase P), were investigated using a cell-free system from the slime mold Dictyostelium discoideum [2].
Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease [3].
A cross-linking experiment utilizing a 4-thiouridine-substituted precursor tRNA demonstrated that the 100-kDa protein interacts with the ribonuclease P substrate in a specific fashion [4].

Biological context of SPBC3D6.03c

The specialized ribonuclease Dicer initiates RNA interference by cleaving double-stranded RNA (dsRNA) substrates into small fragments about 25 nucleotides in length [5].
Ribonuclease Activity of Dis3 Is Required for Mitotic Progression and Provides a Possible Link between Heterochromatin and Kinetochore Function [6].

Associations of SPBC3D6.03c with chemical compounds

DNA is recovered from the appropriate fractions by ethanol precipitation, and the redissolved precipitate is incubated with ribonuclease [7].

References

Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Motamedi, M.R., Verdel, A., Colmenares, S.U., Gerber, S.A., Gygi, S.P., Moazed, D. Cell (2004) [Pubmed]
Additive inhibitory effect of calcipotriol and anthralin on ribonuclease P activity. Papadimou, E., Monastirli, A., Tsambaos, D., Drainas, D. Biochem. Pharmacol. (2000) [Pubmed]
Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease. Rotondo, G., Gillespie, M., Frendewey, D. Mol. Gen. Genet. (1995) [Pubmed]
Identification of a 100-kDa protein associated with nuclear ribonuclease P activity in Schizosaccharomyces pombe. Zimmerly, S., Drainas, D., Sylvers, L.A., Söll, D. Eur. J. Biochem. (1993) [Pubmed]
Structural basis for double-stranded RNA processing by Dicer. Macrae, I.J., Zhou, K., Li, F., Repic, A., Brooks, A.N., Cande, W.Z., Adams, P.D., Doudna, J.A. Science (2006) [Pubmed]
Ribonuclease Activity of Dis3 Is Required for Mitotic Progression and Provides a Possible Link between Heterochromatin and Kinetochore Function. Murakami, H., Goto, D.B., Toda, T., Chen, E.S., Grewal, S.I., Martienssen, R.A., Yanagida, M. PLoS ONE (2007) [Pubmed]
Isolation of DNA from yeasts. Mann, W., Jeffery, J. Anal. Biochem. (1989) [Pubmed]

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