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Gene Review

trz2  -  mitochondrial 3'-tRNA processing...

Schizosaccharomyces pombe 972h-

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High impact information on SPBC3D6.03c


Biological context of SPBC3D6.03c

  • The specialized ribonuclease Dicer initiates RNA interference by cleaving double-stranded RNA (dsRNA) substrates into small fragments about 25 nucleotides in length [5].
  • Ribonuclease Activity of Dis3 Is Required for Mitotic Progression and Provides a Possible Link between Heterochromatin and Kinetochore Function [6].

Associations of SPBC3D6.03c with chemical compounds

  • DNA is recovered from the appropriate fractions by ethanol precipitation, and the redissolved precipitate is incubated with ribonuclease [7].


  1. Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Motamedi, M.R., Verdel, A., Colmenares, S.U., Gerber, S.A., Gygi, S.P., Moazed, D. Cell (2004) [Pubmed]
  2. Additive inhibitory effect of calcipotriol and anthralin on ribonuclease P activity. Papadimou, E., Monastirli, A., Tsambaos, D., Drainas, D. Biochem. Pharmacol. (2000) [Pubmed]
  3. Rescue of the fission yeast snRNA synthesis mutant snm1 by overexpression of the double-strand-specific Pac1 ribonuclease. Rotondo, G., Gillespie, M., Frendewey, D. Mol. Gen. Genet. (1995) [Pubmed]
  4. Identification of a 100-kDa protein associated with nuclear ribonuclease P activity in Schizosaccharomyces pombe. Zimmerly, S., Drainas, D., Sylvers, L.A., Söll, D. Eur. J. Biochem. (1993) [Pubmed]
  5. Structural basis for double-stranded RNA processing by Dicer. Macrae, I.J., Zhou, K., Li, F., Repic, A., Brooks, A.N., Cande, W.Z., Adams, P.D., Doudna, J.A. Science (2006) [Pubmed]
  6. Ribonuclease Activity of Dis3 Is Required for Mitotic Progression and Provides a Possible Link between Heterochromatin and Kinetochore Function. Murakami, H., Goto, D.B., Toda, T., Chen, E.S., Grewal, S.I., Martienssen, R.A., Yanagida, M. PLoS ONE (2007) [Pubmed]
  7. Isolation of DNA from yeasts. Mann, W., Jeffery, J. Anal. Biochem. (1989) [Pubmed]
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