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Gene Review:

pcr1 - transcription factor Pcr1

Schizosaccharomyces pombe 972h-

Neely, L.A. et al., Watanabe, Y. et al., Jia, S. et al.

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High impact information on pcr1

Upstream activation site 1 (UAS1), located approximately 900 bp from the transcriptional start site, resembles a cAMP response element (CRE) that is the binding site for the atf1-pcr1 heterodimeric transcriptional activator [1].
Furthermore, disruption of pcr1 reduced expression of fbp1, a glucose-repressible gene negatively regulated by PKA [2].
Disruption of pcr1 blocked ectopic sexual development [2].
The Schizosaccharomyces pombe pcr1 gene encodes a bZIP protein that apparently belongs to the cyclic AMP response element (CRE)-binding protein/activating transcription factor family [2].
Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development [2].

Biological context of pcr1

Deletion of atf1 or pcr1 alone has little effect on silencing at the mating-type region, but when combined with RNAi mutants, double mutants fail to nucleate heterochromatin assembly [3].

References

Protein kinase A and mitogen-activated protein kinase pathways antagonistically regulate fission yeast fbp1 transcription by employing different modes of action at two upstream activation sites. Neely, L.A., Hoffman, C.S. Mol. Cell. Biol. (2000) [Pubmed]
Schizosaccharomyces pombe pcr1+ encodes a CREB/ATF protein involved in regulation of gene expression for sexual development. Watanabe, Y., Yamamoto, M. Mol. Cell. Biol. (1996) [Pubmed]
RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Jia, S., Noma, K., Grewal, S.I. Science (2004) [Pubmed]

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