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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

OR6C3  -  olfactory receptor, family 6, subfamily C,...

Homo sapiens

Synonyms: HSA8, OST709, Olfactory receptor 6C3
 
 
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High impact information on OR6C3

  • The homology of the SSC17 pericentromeric region was extended to other human chromosomes (HSA4, HSA8) and the chromosomal breakpoint boundaries were accurately defined [1].
  • Gene assignments on BTA27 and the localization of 8 more genes on BTA8 and BTA14 previously predicted on BTA8/BTA27 and BTA14/BTA27 narrowed down significantly the chromosome break points between the three cattle chromosomes and segments on Homo sapiens chromosomes HSA4 and HSA8 [2].
  • Comparative analysis revealed that gene order is very well conserved across SSC4 compared to both HSA1 and HSA8 [3].
  • No remnants of the HSA1 centromere were detected on the corresponding region on SSC4 and traces from the centromeric region of SSC4 cannot clearly be revealed on the homologous region on HSA8 [3].
  • A synteny of segments homologous to parts of HSA4 and HSA8 was observed in zebra and horse [4].
 

Associations of OR6C3 with chemical compounds

  • In particular, HSA 8, HSA 10, HSA 11, and HSA 16+7 paint, respectively, BBU 1p, BBU 4p, BBU 5p, and BBU 24, which are homoeologous, respectively, to cattle chromosomes 25, 28, 29 and 27 [5].

References

  1. A high-resolution comparative map between pig chromosome 17 and human chromosomes 4, 8, and 20: identification of synteny breakpoints. Lahbib-Mansais, Y., Karlskov-Mortensen, P., Mompart, F., Milan, D., Jørgensen, C.B., Cirera, S., Gorodkin, J., Faraut, T., Yerle, M., Fredholm, M. Genomics (2005) [Pubmed]
  2. High-resolution comparative mapping between human chromosomes 4 and 8 and bovine chromosome 27 provides genes and segments serving as positional candidates for udder health in cattle. Goldammer, T., Kata, S.R., Brunner, R.M., Kühn, C., Weikard, R., Womack, J.E., Schwerin, M. Genomics (2004) [Pubmed]
  3. High-resolution comparative mapping of pig Chromosome 4, emphasizing the FAT1 region. Moller, M., Berg, F., Riquet, J., Pomp, D., Archibald, A., Anderson, S., Feve, K., Zhang, Y., Rothschild, M., Milan, D., Andersson, L., Tuggle, C.K. Mamm. Genome (2004) [Pubmed]
  4. Chromosome homologies between man and mountain zebra (Equus zebra hartmannae) and description of a new ancestral synteny involving sequences homologous to human chromosomes 4 and 8. Richard, F., Messaoudi, C., Lombard, M., Dutrillaux, B. Cytogenet. Cell Genet. (2001) [Pubmed]
  5. ZOO-FISH and R-banding reveal extensive conservation of human chromosome regions in euchromatic regions of river buffalo chromosomes. Iannuzzi, L., Di Meo, G.P., Perucatti, A., Bardaro, T. Cytogenet. Cell Genet. (1998) [Pubmed]
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