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Gene Review

Pnoc  -  prepronociceptin

Rattus norvegicus

Synonyms: N23K, Npnc1, Prepronociceptin
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Disease relevance of Pnoc


High impact information on Pnoc

  • 1. Whole-cell patch clamp recordings were made from rat rostral ventromedial medulla (RVM) neurons in vitro to investigate the cellular actions of the opioid-like receptor ORL1 (NOP), ligand nociceptin/orphanin FQ and other putative prepronociceptin products [2].
  • Although little or no expression of prepronociceptin mRNA was observed in the dorsal root ganglia of naive animals, carrageenan-elicited inflammation markedly induced its expression, peaking within 30 min, a time when nociceptive hypersensitivity was not yet apparent [1].
  • The present experiments were conducted to determine the localization of PPN mRNA in primary sensory neurons after peripheral inflammation, using in situ hybridization [3].

Analytical, diagnostic and therapeutic context of Pnoc


  1. Nociceptin gene expression in rat dorsal root ganglia induced by peripheral inflammation. Andoh, T., Itoh, M., Kuraishi, Y. Neuroreport (1997) [Pubmed]
  2. Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro. Vaughan, C.W., Connor, M., Jennings, E.A., Marinelli, S., Allen, R.G., Christie, M.J. J. Physiol. (Lond.) (2001) [Pubmed]
  3. Induction by carrageenan inflammation of prepronociceptin mRNA in VR1-immunoreactive neurons in rat dorsal root ganglia. Itoh, M., Takasaki, I., Andoh, T., Nojima, H., Tominaga, M., Kuraishi, Y. Neurosci. Res. (2001) [Pubmed]
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