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Gene Review

Pnoc  -  prepronociceptin

Mus musculus

Synonyms: N/OFQ, N23K, N23K/N27K, Npnc1, OFQ/N, ...
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Disease relevance of Pnoc


High impact information on Pnoc


Chemical compound and disease context of Pnoc


Biological context of Pnoc

  • These studies suggest that the N23K and F44S mutant proteins of SEB are less biologically active than the wild-type toxin, yet retain epitopes useful for eliciting a protective antibody response [7].

Anatomical context of Pnoc


Other interactions of Pnoc


Analytical, diagnostic and therapeutic context of Pnoc


  1. Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor. Depner, U.B., Reinscheid, R.K., Takeshima, H., Brune, K., Zeilhofer, H.U. Eur. J. Neurosci. (2003) [Pubmed]
  2. Regulation of the prepronociceptin gene and its effect on neuronal differentiation. Zaveri, N.T., Waleh, N., Toll, L. Gene (2006) [Pubmed]
  3. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Manabe, T., Noda, Y., Mamiya, T., Katagiri, H., Houtani, T., Nishi, M., Noda, T., Takahashi, T., Sugimoto, T., Nabeshima, T., Takeshima, H. Nature (1998) [Pubmed]
  4. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Mollereau, C., Simons, M.J., Soularue, P., Liners, F., Vassart, G., Meunier, J.C., Parmentier, M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Molecular cloning and characterization of a novel form of neuropeptide gene as a developmentally regulated molecule. Saito, Y., Maruyama, K., Kawano, H., Hagino-Yamagishi, K., Kawamura, K., Saido, T.C., Kawashima, S. J. Biol. Chem. (1996) [Pubmed]
  6. Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats. Nakagawa, T., Kaneko, M., Inamura, S., Satoh, M. Neurosci. Lett. (1999) [Pubmed]
  7. Staphylococcal enterotoxin B mutants (N23K and F44S): biological effects and vaccine potential in a mouse model. Woody, M.A., Krakauer, T., Stiles, B.G. Vaccine (1997) [Pubmed]
  8. Intradermal nociceptin elicits itch-associated responses through leukotriene B(4) in mice. Andoh, T., Yageta, Y., Takeshima, H., Kuraishi, Y. J. Invest. Dermatol. (2004) [Pubmed]
  9. Distribution of the nociceptin and nocistatin precursor transcript in the mouse central nervous system. Boom, A., Mollereau, C., Meunier, J.C., Vassart, G., Parmentier, M., Vanderhaeghen, J.J., Schiffmann, S.N. Neuroscience (1999) [Pubmed]
  10. N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Saito, Y., Maruyama, K., Saido, T.C., Kawashima, S. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  11. Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth. Ring, R.H., Alder, J., Fennell, M., Kouranova, E., Black, I.B., Thakker-Varia, S. J. Neurobiol. (2006) [Pubmed]
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