The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Wolffian Duct

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Wolffian Duct


High impact information on Wolffian Duct


Biological context of Wolffian Duct


Anatomical context of Wolffian Duct


Associations of Wolffian Duct with chemical compounds


Gene context of Wolffian Duct

  • In situ hybridization experiments using mouse embryos showed that during kidney development, Klf6 was expressed selectively in the Wolffian duct and in its derivatives [19].
  • We find that chicken Dmrt1 is expressed in the genital ridge and Wolffian duct prior to sexual differentiation and is expressed at higher levels in ZZ than in ZW embryos [20].
  • The addition of Gdnf protein to urogenital tracts taken from Gdf11 null embryos induced ectopic ureteric bud formation along the Wolffian duct [21].
  • Applied locally on agarose beads, neurturin induces supernumerary ureteric buds to emerge from the wolffian duct and causes nearby collecting duct branches to distend to an abnormally large diameter [22].
  • However, the Wolffian duct from Wt1 -/- embryos was a competent inducer of wild-type metanephric mesenchyme [23].

Analytical, diagnostic and therapeutic context of Wolffian Duct


  1. The androgen receptor in the fetal epididymis is similar to that in the mature rabbit. George, F.W., Peterson, K.G., Frenkel, P.A., Wilson, J.D. Proc. Soc. Exp. Biol. Med. (1988) [Pubmed]
  2. Effects of an environmental endocrine disruptor on fetal development, estrogen receptor(alpha) and epidermal growth factor receptor expression in the porcine male genital tract. Barthold, J.S., Kryger, J.V., Derusha, A.M., Duel, B.P., Jednak, R., Skafar, D.F. J. Urol. (1999) [Pubmed]
  3. Mystery solved: discovery of a novel integrin ligand in the developing kidney. Miner, J.H. J. Cell Biol. (2001) [Pubmed]
  4. GDNF/Ret signaling and the development of the kidney. Costantini, F., Shakya, R. Bioessays (2006) [Pubmed]
  5. Defects of urogenital development in mice lacking Emx2. Miyamoto, N., Yoshida, M., Kuratani, S., Matsuo, I., Aizawa, S. Development (1997) [Pubmed]
  6. Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development. Schuchardt, A., D'Agati, V., Pachnis, V., Costantini, F. Development (1996) [Pubmed]
  7. Induction of functional cytodifferentiation in the epithelium of tissue recombinants. II. Instructive induction of Wolffian duct epithelia by neonatal seminal vesicle mesenchyme. Higgins, S.J., Young, P., Cunha, G.R. Development (1989) [Pubmed]
  8. Characterization of Pax-2 regulatory sequences that direct transgene expression in the Wolffian duct and its derivatives. Kuschert, S., Rowitch, D.H., Haenig, B., McMahon, A.P., Kispert, A. Dev. Biol. (2001) [Pubmed]
  9. Expression of a renin/GFP transgene in mouse embryonic, extra-embryonic, and adult tissues. Jones, C.A., Hurley, M.I., Black, T.A., Kane, C.M., Pan, L., Pruitt, S.C., Gross, K.W. Physiol. Genomics (2000) [Pubmed]
  10. Expression of insulin, insulin-like growth factor I and glucocorticoid receptor in rat uterus and embryo during decidualization, implantation and organogenesis. Korgun, E.T., Dohr, G., Desoye, G., Demir, R., Kayisli, U.A., Hahn, T. Reproduction (2003) [Pubmed]
  11. Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. Sullivan, P.M., Petrusz, P., Szpirer, C., Joseph, D.R. J. Biol. Chem. (1991) [Pubmed]
  12. Immunological identification of the protein-producing masculine differentiation of the Wolffian duct in the fetal mouse: western blot analysis and determination of the biological activity. Gupta, C., Bentlejewski, C. Endocrinology (1993) [Pubmed]
  13. Proteomic analysis of androgen-regulated protein expression in a mouse fetal vas deferens cell line. Umar, A., Luider, T.M., Berrevoets, C.A., Grootegoed, J.A., Brinkmann, A.O. Endocrinology (2003) [Pubmed]
  14. Residual activity of mutant androgen receptors explains wolffian duct development in the complete androgen insensitivity syndrome. Hannema, S.E., Scott, I.S., Hodapp, J., Martin, H., Coleman, N., Schwabe, J.W., Hughes, I.A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  15. 5 alpha-reductase activity in developing urogenital tracts of fetal and neonatal male mice. Tsuji, M., Shima, H., Terada, N., Cunha, G.R. Endocrinology (1994) [Pubmed]
  16. Role of prostaglandins in the testosterone-dependent wolffian duct differentiation of the fetal mouse. Gupta, C., Bentlejewski, C.A. Biol. Reprod. (1992) [Pubmed]
  17. Anti-masculinizing action of estradiol and cyproterone acetate: regulation of a protein fraction with phospholipase-A2 stimulatory and masculinizing activities. Gupta, C., Wharton, V., Ellis, D. J. Steroid Biochem. Mol. Biol. (1990) [Pubmed]
  18. Molecular basis of androgen insensitivity. Brinkmann, A.O. Mol. Cell. Endocrinol. (2001) [Pubmed]
  19. Klf6 is a zinc finger protein expressed in a cell-specific manner during kidney development. Fischer, E.A., Verpont, M.C., Garrett-Sinha, L.A., Ronco, P.M., Rossert, J.A. J. Am. Soc. Nephrol. (2001) [Pubmed]
  20. Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. Raymond, C.S., Kettlewell, J.R., Hirsch, B., Bardwell, V.J., Zarkower, D. Dev. Biol. (1999) [Pubmed]
  21. Regulation of metanephric kidney development by growth/differentiation factor 11. Esquela, A.F., Lee, S.J. Dev. Biol. (2003) [Pubmed]
  22. Neurturin: an autocrine regulator of renal collecting duct development. Davies, J.A., Millar, C.B., Johnson, E.M., Milbrandt, J. Dev. Genet. (1999) [Pubmed]
  23. Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Donovan, M.J., Natoli, T.A., Sainio, K., Amstutz, A., Jaenisch, R., Sariola, H., Kreidberg, J.A. Dev. Genet. (1999) [Pubmed]
  24. Immunodetection of estrogen receptors in fetal and neonatal male mouse reproductive tracts. Greco, T.L., Furlow, J.D., Duello, T.M., Gorski, J. Endocrinology (1992) [Pubmed]
  25. Localization of protein gene product 9.5 immunoreactivity in derivatives of the human Wolffian duct and in prostate cancer. Aumüller, G., Renneberg, H., Leonhardt, M., Lilja, H., Abrahamsson, P.A. Prostate (1999) [Pubmed]
  26. Cellular localization of immunoreactive epidermal growth factor during Wolffian duct differentiation of the fetal mouse. Gupta, C. Urol. Res. (1997) [Pubmed]
WikiGenes - Universities