Disease relevance of SHPRH

• Such a role for SHPRH is consistent with the observation that this gene is mutated in a number of cancer cell lines, including those from melanomas and ovarian cancers, which raises the strong possibility that SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans [1].

High impact information on SHPRH

• Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination [2].
• Therefore, the yRad5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress [2].
• We report that a putative tumor suppressor gene, SHPRH, is a human orthologue of yeast RAD5 [2].
• Human SHPRH gene is located at the 6q24 chromosomal region, and loss of heterozygosity in this region is seen in a wide variety of cancers [1].

Biological context of SHPRH

• The reduction of SHPRH by stable short hairpin RNA increases sensitivity to MMS and enhances genomic instability [2].

References