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Gene Review

SHPRH  -  SNF2 histone linker PHD RING helicase, E3...

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase SHPRH, FLJ90837, KIAA2023, SNF2, histone-linker, PHD and RING finger domain-containing helicase, bA545I5.2
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Disease relevance of SHPRH

  • Such a role for SHPRH is consistent with the observation that this gene is mutated in a number of cancer cell lines, including those from melanomas and ovarian cancers, which raises the strong possibility that SHPRH function is an important deterrent to mutagenesis and carcinogenesis in humans [1].

High impact information on SHPRH


Biological context of SHPRH


  1. Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen. Unk, I., Hajd??, I., F??tyol, K., Szak??l, B., Blasty??k, A., Bermudez, V., Hurwitz, J., Prakash, L., Prakash, S., Haracska, L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination. Motegi, A., Sood, R., Moinova, H., Markowitz, S.D., Liu, P.P., Myung, K. J. Cell Biol. (2006) [Pubmed]
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