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Gene Review

SUN2  -  Sad1 and UNC84 domain containing 2

Homo sapiens

Synonyms: FRIGG, KIAA0668, Protein unc-84 homolog B, RAB5IP, Rab5-interacting protein, ...
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High impact information on UNC84B


Biological context of UNC84B

  • Three of these differentially amplified fragments matched cDNA sequences coding for proteins of unknown function in humans: hCALO (human homologue of calossin), NP79 (coding for a nuclear protein of 79KD) and SUN2 (Sad-1 unc-84 domain protein 2) [3].
  • SUN1 can suppress a null nin1 mutation, whereas SUN2, an essential gene, does not [4].

Anatomical context of UNC84B


Associations of UNC84B with chemical compounds


Other interactions of UNC84B

  • Furthermore, the SUN2 protein can form different assemblies, including homodimers and heterodimers with SUN1 [5].


  1. Sun2 is a novel mammalian inner nuclear membrane protein. Hodzic, D.M., Yeater, D.B., Bengtsson, L., Otto, H., Stahl, P.D. J. Biol. Chem. (2004) [Pubmed]
  2. A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion. Hoffenberg, S., Liu, X., Nikolova, L., Hall, H.S., Dai, W., Baughn, R.E., Dickey, B.F., Barbieri, M.A., Aballay, A., Stahl, P.D., Knoll, B.J. J. Biol. Chem. (2000) [Pubmed]
  3. Isolation of differentially expressed genes in human heart tissues. Sun, G., Yuen Chan, S., Yuan, Y., Wang Chan, K., Qiu, G., Sun, K., Ping Leung, M. Biochim. Biophys. Acta (2002) [Pubmed]
  4. Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1. Kominami, K., Okura, N., Kawamura, M., DeMartino, G.N., Slaughter, C.A., Shimbara, N., Chung, C.H., Fujimuro, M., Yokosawa, H., Shimizu, Y., Tanahashi, N., Tanaka, K., Toh-e, A. Mol. Biol. Cell (1997) [Pubmed]
  5. Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. Wang, Q., Du, X., Cai, Z., Greene, M.I. DNA Cell Biol. (2006) [Pubmed]
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