High impact information on UNC84B

• Electron microscopy analysis shows that Sun2 localizes in the nuclear envelope with a sub-population present in small clusters [1].
• Furthermore, Sun2 is enriched in purified HeLa cell nuclei [1].
• Additionally, we show that the SUN domain of Sun2 is localized to the periplasmic space between the inner and the outer nuclear membranes [1].
• The Sun2 antibody signal co-localizes with nuclear pore and INM markers signals [1].
• A novel membrane-anchored Rab5 interacting protein required for homotypic endosome fusion [2].

Biological context of UNC84B

• Three of these differentially amplified fragments matched cDNA sequences coding for proteins of unknown function in humans: hCALO (human homologue of calossin), NP79 (coding for a nuclear protein of 79KD) and SUN2 (Sad-1 unc-84 domain protein 2) [3].
• SUN1 can suppress a null nin1 mutation, whereas SUN2, an essential gene, does not [4].

Anatomical context of UNC84B

• Sun2 is a novel mammalian inner nuclear membrane protein [1].
• Finally, we provide evidence indicating that SUN1 and SUN2 may form a physical interaction between the nuclear envelope and the centrosome [5].

Associations of UNC84B with chemical compounds

• During glycerol density gradient centrifugation, both Sun1p and Sun2p comigrated with the known proteasome components [4].

Other interactions of UNC84B

• Furthermore, the SUN2 protein can form different assemblies, including homodimers and heterodimers with SUN1 [5].

References