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Gene Review

FAM162A  -  family with sequence similarity 162, member A

Homo sapiens

Synonyms: C3orf28, DC16, E2-induced gene 5 protein, E2IG5, FWP001, ...
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Disease relevance of C3orf28

  • We performed this work to elucidate the effects of the pro-apoptotic protein HGTD-P on neuronal cell death induced by hypoxia and to investigate the cell death mechanisms activated during this process [1].

High impact information on C3orf28


Associations of C3orf28 with chemical compounds

  • To date at least six BH3-only proteins have been shown to contribute to ischemia-reperfusion death pathways in heart and/or brain; these include Bnip3, PUMA, Bid, Bad, HGTD-P, and Noxa [4].


  1. mHGTD-P mediates hypoxic neuronal cell death via the release of apoptosis-inducing factor. Cho, Y.E., Ko, J.H., Kim, Y.J., Yim, J.H., Kim, S.M., Park, J.H. Neurosci. Lett. (2007) [Pubmed]
  2. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Lee, M.J., Kim, J.Y., Suk, K., Park, J.H. Mol. Cell. Biol. (2004) [Pubmed]
  3. Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. Kim, J.Y., Kim, S.M., Ko, J.H., Yim, J.H., Park, J.H., Park, J.H. FEBS Lett. (2006) [Pubmed]
  4. Redox Stress and the Contributions of BH3-Only Proteins to Infarction. Webster, K.A., Graham, R.M., Thompson, J.W., Spiga, M.G., Frazier, D.P., Wilson, A., Bishopric, N.H. Antioxid. Redox Signal. (2006) [Pubmed]
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