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Gene Review:

FAM162A - family with sequence similarity 162, member A

Homo sapiens

Synonyms: C3orf28, DC16, E2-induced gene 5 protein, E2IG5, FWP001, ...

Lee, M.J. et al., Cho, Y.E. et al., Webster, K.A. et al., Kim, J.Y. et al.

Webster, Graham, Thompson, Spiga, Frazier, Wilson, Bishopric,

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Disease relevance of C3orf28

We performed this work to elucidate the effects of the pro-apoptotic protein HGTD-P on neuronal cell death induced by hypoxia and to investigate the cell death mechanisms activated during this process [1].

High impact information on C3orf28

Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway [2].
In the process of permeability transition induction, the death-inducing domain of HGTD-P physically interacted with the voltage-dependent anion channel [2].
In addition, suppression of HGTD-P expression by small interfering RNA or antisense oligonucleotides protected against hypoxic cell death [2].
Its expression was directly regulated by HIF-1 alpha through a hypoxia-responsive element on the HGTD-P promoter region [2].
HGTD-P is a hypoxia-responsive pro-apoptotic protein that transmits hypoxic signals directly to mitochondria [3].

Associations of C3orf28 with chemical compounds

To date at least six BH3-only proteins have been shown to contribute to ischemia-reperfusion death pathways in heart and/or brain; these include Bnip3, PUMA, Bid, Bad, HGTD-P, and Noxa [4].

References

mHGTD-P mediates hypoxic neuronal cell death via the release of apoptosis-inducing factor. Cho, Y.E., Ko, J.H., Kim, Y.J., Yim, J.H., Kim, S.M., Park, J.H. Neurosci. Lett. (2007) [Pubmed]
Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Lee, M.J., Kim, J.Y., Suk, K., Park, J.H. Mol. Cell. Biol. (2004) [Pubmed]
Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. Kim, J.Y., Kim, S.M., Ko, J.H., Yim, J.H., Park, J.H., Park, J.H. FEBS Lett. (2006) [Pubmed]
Redox Stress and the Contributions of BH3-Only Proteins to Infarction. Webster, K.A., Graham, R.M., Thompson, J.W., Spiga, M.G., Frazier, D.P., Wilson, A., Bishopric, N.H. Antioxid. Redox Signal. (2006) [Pubmed]

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FAM162A	Bos taurus
FAM162A	Canis lupus familiaris
fam162a	Danio rerio
FAM162A	Gallus gallus
FAM162A	Macaca mulatta
Fam162a	Mus musculus
FAM162A	Pan troglodytes
Fam162a	Rattus norvegicus
LOC100490517	Xenopus (Silurana) tropicalis

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