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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RGS17  -  regulator of G-protein signaling 17

Homo sapiens

Synonyms: RGS-17, RGSZ2, Regulator of G-protein signaling 17, hRGS17
 
 
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Disease relevance of RGS17

 

High impact information on RGS17

  • The fusion gene encodes the full-length RGS17 protein, a regulator of G protein-coupled signaling, under the control of the IRA1 gene promoter [1].
  • This review focuses on RGS17 and its RZ/A sibling proteins and discusses the similarities and differences among these proteins in terms of their palmitoylation, phosphorylation, intracellular localization and interactions with GPCRs and adapter proteins [2].
  • In contrast, analysis of the medial frontal cortex (MFC) revealed a significant decrease in Rgs17 expression exclusively, and a modest up-regulation of Rgs5 transcript [3].
  • RGS7 and RGS17 had overlapping distribution profiles and were both noticeably enriched in the cerebellum [4].
 

Analytical, diagnostic and therapeutic context of RGS17

References

  1. Finding fusion genes resulting from chromosome rearrangement by analyzing the expressed sequence databases. Hahn, Y., Bera, T.K., Gehlhaus, K., Kirsch, I.R., Pastan, I.H., Lee, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. RGS17/RGSZ2 and the RZ/A family of regulators of G-protein signaling. Nunn, C., Mao, H., Chidiac, P., Albert, P.R. Semin. Cell Dev. Biol. (2006) [Pubmed]
  3. Genetic or pharmacological inactivation of the dopamine D1 receptor differentially alters the expression of regulator of G-protein signalling (Rgs) transcripts. Stanwood, G.D., Parlaman, J.P., Levitt, P. Eur. J. Neurosci. (2006) [Pubmed]
  4. Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. Larminie, C., Murdock, P., Walhin, J.P., Duckworth, M., Blumer, K.J., Scheideler, M.A., Garnier, M. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  5. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. Mao, H., Zhao, Q., Daigle, M., Ghahremani, M.H., Chidiac, P., Albert, P.R. J. Biol. Chem. (2004) [Pubmed]
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