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Gene Review

VCX  -  variable charge, X-linked

Homo sapiens

Synonyms: VCX-10r, VCX-B1, VCX1, VCX10R, VCXB1, ...
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Disease relevance of VCX

  • The revelation that CRI-S232 contains VCX offers a more precise description of the genetic etiology of X-linked ichthyosis: it results from aberrant recombination between VCX gene arrays that flank the STS locus [1].

Psychiatry related information on VCX


High impact information on VCX

  • There is no correlation between the presence or absence of VCX-B1, -B, and VCX-C and mental status in our patients [3].
  • Array-CGH with DNA of an XLI patient with MR and an inherited t(X;Y)(p22.31;q11.2) showed an Xpter deletion of 8.0 Mb resulting in the deletion of all four VCX genes and duplication of both VCY homologs [4].
  • Analysis of DNA from four XLI patients with MR by array-comparative genomic hybridization (array-CGH) on a 150 kb resolution X chromosome-specific array revealed a 1.5 Mb interstitial microdeletion with breakpoints in the CRI-S232 repeat sequences, each of which harbors a VCX gene [4].
  • We also found that a copy of VCX is present in CRI-S232, a previously described genomic fragment derived from the X chromosome [1].
  • Designated VCX / Y ( Variable Charge X / Y; VCY previously known as BPY1 ), this gene family has multiple members on both X and Y, and all appear to be expressed exclusively in male germ cells [1].

Biological context of VCX


Other interactions of VCX

  • The location of each CAIII locus in a Low Copy Repeated element containing duplicated VCX/Y genes (approximately 1 kb) suggested that direct or indirect selection could explain these results [6].


  1. A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins. Lahn, B.T., Page, D.C. Hum. Mol. Genet. (2000) [Pubmed]
  2. Xp22.3 microdeletion including VCX-A and VCX-B1 genes in an X-linked ichthyosis family: no difference in deletion size for patients with and without mental retardation. Lesca, G., Sinilnikova, O., Theuil, G., Blanc, J., Edery, P., Till, M. Clin. Genet. (2005) [Pubmed]
  3. A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation. Fukami, M., Kirsch, S., Schiller, S., Richter, A., Benes, V., Franco, B., Muroya, K., Rao, E., Merker, S., Niesler, B., Ballabio, A., Ansorge, W., Ogata, T., Rappold, G.A. Am. J. Hum. Genet. (2000) [Pubmed]
  4. Deletion of VCX-A due to NAHR plays a major role in the occurrence of mental retardation in patients with X-linked ichthyosis. Van Esch, H., Hollanders, K., Badisco, L., Melotte, C., Van Hummelen, P., Vermeesch, J.R., Devriendt, K., Fryns, J.P., Marynen, P., Froyen, G. Hum. Mol. Genet. (2005) [Pubmed]
  5. Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis. Zou, S.W., Zhang, J.C., Zhang, X.D., Miao, S.Y., Zong, S.D., Sheng, Q., Wang, L.F. Cell Res. (2003) [Pubmed]
  6. Evolutionary dynamics of duplicated microsatellites shared by sex chromosomes. Balaresque, P., Toupance, B., Heyer, E., Crouau-Roy, B. J. Mol. Evol. (2003) [Pubmed]
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