The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nucleic Acid Hybridization

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nucleic Acid Hybridization


High impact information on Nucleic Acid Hybridization

  • Here we show that comparative genomic hybridization to DNA microarrays (array CGH) overcomes these limitations by allowing efficient, genome-wide analyses of relative genome copy number [6].
  • Comparative genomic hybridization shows that amplification of the Xq11-q13 region (the location), is common in tumours recurring during androgen deprivation therapy [7].
  • A KAP cDNA fragment was purified and used for nucleic acid hybridization studies [8].
  • Nucleic acid hybridization analysis with a cDNA probe specific for the constant region of kappa light chains revealed that microsomal RNA from the wild-type cell contains both 14S and a 10S species of kappa specific RNA, whereas the variant contains only the 10S species [9].
  • METHODS: Comparative genomic hybridization (CGH) was used to analyze 31 pairs of initial and recurrent HCC samples obtained from patients undergoing 2 consecutive surgeries [10].

Chemical compound and disease context of Nucleic Acid Hybridization


Biological context of Nucleic Acid Hybridization


Anatomical context of Nucleic Acid Hybridization


Associations of Nucleic Acid Hybridization with chemical compounds


Gene context of Nucleic Acid Hybridization


Analytical, diagnostic and therapeutic context of Nucleic Acid Hybridization


  1. Epstein-Barr virus genome studies in Burkitt's and non-Burkitt's lymphomas in Uganda. Olweny, C.L., Atine, I., Kaddu-Mukasa, A., Owor, R., Andersson-Anvret, M., Klein, G., Henle, W., de-Thé, G. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Pollack, J.R., Sørlie, T., Perou, C.M., Rees, C.A., Jeffrey, S.S., Lonning, P.E., Tibshirani, R., Botstein, D., Børresen-Dale, A.L., Brown, P.O. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Genomic stability and functional activity may be lost in telomerase-transduced human CD8+ T lymphocytes. Schreurs, M.W., Hermsen, M.A., Geltink, R.I., Scholten, K.B., Brink, A.A., Kueter, E.W., Tijssen, M., Meijer, C.J., Ylstra, B., Meijer, G.A., Hooijberg, E. Blood (2005) [Pubmed]
  4. Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cher, M.L., Bova, G.S., Moore, D.H., Small, E.J., Carroll, P.R., Pin, S.S., Epstein, J.I., Isaacs, W.B., Jensen, R.H. Cancer Res. (1996) [Pubmed]
  5. Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors. Wessels, L.F., van Welsem, T., Hart, A.A., van't Veer, L.J., Reinders, M.J., Nederlof, P.M. Cancer Res. (2002) [Pubmed]
  6. Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas. Hodgson, G., Hager, J.H., Volik, S., Hariono, S., Wernick, M., Moore, D., Nowak, N., Albertson, D.G., Pinkel, D., Collins, C., Hanahan, D., Gray, J.W. Nat. Genet. (2001) [Pubmed]
  7. In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Visakorpi, T., Hyytinen, E., Koivisto, P., Tanner, M., Keinänen, R., Palmberg, C., Palotie, A., Tammela, T., Isola, J., Kallioniemi, O.P. Nat. Genet. (1995) [Pubmed]
  8. An abundant androgen-regulated mRNA in the mouse kidney. Toole, J.J., Hastie, N.D., Held, W.A. Cell (1979) [Pubmed]
  9. Characterization of light chain and light chain constant region fragment mRNAs in MPC 11 mouse myeloma cells and variants. Kuehl, W.M., Kaplan, B.A., Scharff, M.D. Cell (1975) [Pubmed]
  10. Chromosomal changes and clonality relationship between primary and recurrent hepatocellular carcinoma. Chen, Y.J., Yeh, S.H., Chen, J.T., Wu, C.C., Hsu, M.T., Tsai, S.F., Chen, P.J., Lin, C.H. Gastroenterology (2000) [Pubmed]
  11. Candidate genes in breast cancer revealed by microarray-based comparative genomic hybridization of archived tissue. Nessling, M., Richter, K., Schwaenen, C., Roerig, P., Wrobel, G., Wessendorf, S., Fritz, B., Bentz, M., Sinn, H.P., Radlwimmer, B., Lichter, P. Cancer Res. (2005) [Pubmed]
  12. Helicobacter pylori-related and -non-related gastric cancers do not differ with respect to chromosomal aberrations. van Grieken, N.C., Weiss, M.M., Meijer, G.A., Hermsen, M.A., Scholte, G.H., Lindeman, J., Craanen, M.E., Bloemena, E., Meuwissen, S.G., Baak, J.P., Kuipers, E.J. J. Pathol. (2000) [Pubmed]
  13. Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid. Huang, E.S. J. Virol. (1975) [Pubmed]
  14. Excretion of hepatitis A virus (HAV) in adults: comparison of immunologic and molecular detection methods and relationship between HAV positivity and infectivity in tamarins. Polish, L.B., Robertson, B.H., Khanna, B., Krawczynski, K., Spelbring, J., Olson, F., Shapiro, C.N. J. Clin. Microbiol. (1999) [Pubmed]
  15. Comparative genomic hybridization of ectopic pregnancies that fail methotrexate therapy. McKenzie, L.J., El-Zimaity, H., Krotz, S., Laucirica, R., Carson, S., Buster, J.E. Fertil. Steril. (2005) [Pubmed]
  16. High-resolution molecular characterization of 15q11-q13 rearrangements by array comparative genomic hybridization (array CGH) with detection of gene dosage. Wang, N.J., Liu, D., Parokonny, A.S., Schanen, N.C. Am. J. Hum. Genet. (2004) [Pubmed]
  17. E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas. Bain, G., Engel, I., Robanus Maandag, E.C., te Riele, H.P., Voland, J.R., Sharp, L.L., Chun, J., Huey, B., Pinkel, D., Murre, C. Mol. Cell. Biol. (1997) [Pubmed]
  18. Molecular cytogenetic analysis of formalin-fixed, paraffin-embedded solid tumors by comparative genomic hybridization after universal DNA-amplification. Speicher, M.R., du Manoir, S., Schröck, E., Holtgreve-Grez, H., Schoell, B., Lengauer, C., Cremer, T., Ried, T. Hum. Mol. Genet. (1993) [Pubmed]
  19. Identification of disease genes by whole genome CGH arrays. Vissers, L.E., Veltman, J.A., van Kessel, A.G., Brunner, H.G. Hum. Mol. Genet. (2005) [Pubmed]
  20. MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma. Sanchez-Izquierdo, D., Buchonnet, G., Siebert, R., Gascoyne, R.D., Climent, J., Karran, L., Marin, M., Blesa, D., Horsman, D., Rosenwald, A., Staudt, L.M., Albertson, D.G., Du, M.Q., Ye, H., Marynen, P., Garcia-Conde, J., Pinkel, D., Dyer, M.J., Martinez-Climent, J.A. Blood (2003) [Pubmed]
  21. Correlation of microscopic phenotype with genotype in a formalin-fixed, paraffin-embedded testicular germ cell tumor with universal DNA amplification, comparative genomic hybridization, and interphase cytogenetics. Speicher, M.R., Jauch, A., Walt, H., du Manoir, S., Ried, T., Jochum, W., Sulser, T., Cremer, T. Am. J. Pathol. (1995) [Pubmed]
  22. Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma. Snijders, A.M., Nowee, M.E., Fridlyand, J., Piek, J.M., Dorsman, J.C., Jain, A.N., Pinkel, D., van Diest, P.J., Verheijen, R.H., Albertson, D.G. Oncogene (2003) [Pubmed]
  23. Gain of 1q and loss of 9q21.3-q32 are associated with a less favorable prognosis in papillary thyroid carcinoma. Kjellman, P., Lagercrantz, S., Höög, A., Wallin, G., Larsson, C., Zedenius, J. Genes Chromosomes Cancer (2001) [Pubmed]
  24. Analysis of chromosomal imbalances in sporadic and NF1-associated peripheral nerve sheath tumors by comparative genomic hybridization. Mechtersheimer, G., Otaño-Joos, M., Ohl, S., Benner, A., Lehnert, T., Willeke, F., Möller, P., Otto, H.F., Lichter, P., Joos, S. Genes Chromosomes Cancer (1999) [Pubmed]
  25. Molecular cloning, sequencing, and expression of the 36 kDa protein present in pars planitis. Sequence homology with yeast nucleopore complex protein. Bora, N.S., Bora, P.S., Tandhasetti, M.T., Cirrito, T.P., Kaplan, H.J. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  26. Herpes simplex virus resistant to acyclovir. A study in a tertiary care center. Englund, J.A., Zimmerman, M.E., Swierkosz, E.M., Goodman, J.L., Scholl, D.R., Balfour, H.H. Ann. Intern. Med. (1990) [Pubmed]
  27. Molecular basis for increased synthesis of albumin in rat liver after thioacetamide administration. Chakrabarty, P.K., Chattopadhyay, S.K., Schneider, W.C. Cancer Res. (1982) [Pubmed]
  28. Detection of viral DNA by in situ hybridization using bromodeoxyuridine-labeled DNA probes. Niedobitek, G., Finn, T., Herbst, H., Bornhöft, G., Gerdes, J., Stein, H. Am. J. Pathol. (1988) [Pubmed]
  29. Optimization of excimer-forming two-probe nucleic acid hybridization method with pyrene as a fluorophore. Masuko, M., Ohtani, H., Ebata, K., Shimadzu, A. Nucleic Acids Res. (1998) [Pubmed]
  30. Affinity adsorbents consisting of nucleic acids immobilized via bisoxirane activated polysaccharides. Potuzak, H., Dean, P.D. Nucleic Acids Res. (1978) [Pubmed]
  31. Deletion of VCX-A due to NAHR plays a major role in the occurrence of mental retardation in patients with X-linked ichthyosis. Van Esch, H., Hollanders, K., Badisco, L., Melotte, C., Van Hummelen, P., Vermeesch, J.R., Devriendt, K., Fryns, J.P., Marynen, P., Froyen, G. Hum. Mol. Genet. (2005) [Pubmed]
  32. Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect. Lee, J.A., Madrid, R.E., Sperle, K., Ritterson, C.M., Hobson, G.M., Garbern, J., Lupski, J.R., Inoue, K. Ann. Neurol. (2006) [Pubmed]
  33. High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma. Oda, K., Stokoe, D., Taketani, Y., McCormick, F. Cancer Res. (2005) [Pubmed]
  34. Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth. Zhang, L., Yang, N., Huang, J., Buckanovich, R.J., Liang, S., Barchetti, A., Vezzani, C., O'Brien-Jenkins, A., Wang, J., Ward, M.R., Courreges, M.C., Fracchioli, S., Medina, A., Katsaros, D., Weber, B.L., Coukos, G. Cancer Res. (2005) [Pubmed]
  35. The yeast homolog of mammalian ribosomal protein S30 is expressed from a duplicated gene without a ubiquitin-like protein fusion sequence. Evolutionary implications. Baker, R.T., Williamson, N.A., Wettenhall, R.E. J. Biol. Chem. (1996) [Pubmed]
  36. Molecular forms of N-CAM and its RNA in developing and denervated skeletal muscle. Covault, J., Merlie, J.P., Goridis, C., Sanes, J.R. J. Cell Biol. (1986) [Pubmed]
  37. DNA copy number changes in diffuse large B-cell lymphoma--comparative genomic hybridization study. Monni, O., Joensuu, H., Franssila, K., Knuutila, S. Blood (1996) [Pubmed]
  38. Chromosomal instability in MYH- and APC-mutant adenomatous polyps. Cardoso, J., Molenaar, L., de Menezes, R.X., van Leerdam, M., Rosenberg, C., Möslein, G., Sampson, J., Morreau, H., Boer, J.M., Fodde, R. Cancer Res. (2006) [Pubmed]
  39. Deletion of 11q23 and cyclin D1 overexpression are frequent aberrations in parathyroid adenomas. Hemmer, S., Wasenius, V.M., Haglund, C., Zhu, Y., Knuutila, S., Franssila, K., Joensuu, H. Am. J. Pathol. (2001) [Pubmed]
  40. Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis. Bovée, J.V., Cleton-Jansen, A.M., Rosenberg, C., Taminiau, A.H., Cornelisse, C.J., Hogendoorn, P.C. J. Pathol. (1999) [Pubmed]
WikiGenes - Universities