High impact information on MDGA1

• GPIM gene consists of an 8.9 kb transcript composed of 17 coding exons spanning about 65.5 kb of genomic DNA [1].
• Finally, as other proteins of the secretory pathway, hMDGA1 undergoes other post-translational modification consisting of N-glycosylation [2].
• Moreover, our results reveal that hMDGA1 is localized specifically into membrane microdomains known as lipid rafts [2].
• Our results demonstrate that human MDGA1 (hMDGA1) is localized in the membrane of eukaryotic cells [2].
• The PDAI was validated against physician (MDGA) and patient (PGA) global assessments, and treatment was prescribed for the perianal disease [3].

Biological context of MDGA1

• Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1 [4].
• To test this hypothesis, we performed loss-of-function studies using RNA interference (RNAi) targeting different sequences of mouse MDGA1 [4].
• RNAi transfections of deep layer neurons that do not express MDGA1 do not significantly affect their migration [4].

Anatomical context of MDGA1

• We show in postnatal mice that MDGA1 is expressed by layer 2/3 neurons throughout the neocortex [4].

Associations of MDGA1 with chemical compounds

• MAM (meprin/A5 protein/receptor protein tyrosine phosphatase mu) domain glycosylphosphatidylinositol anchor 1 (MDGA1), a unique cell surface glycoprotein, is similar to Ig-containing cell adhesion molecules that influence neuronal migration and process outgrowth [4].

References