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Gene Review

MDGA1  -  MAM domain containing glycosylphosphatidyl...

Homo sapiens

Synonyms: GPI and MAM protein, GPIM, Glycosylphosphatidylinositol-MAM, MAM domain-containing glycosylphosphatidylinositol anchor protein 1, MAM domain-containing protein 3, ...
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High impact information on MDGA1

  • GPIM gene consists of an 8.9 kb transcript composed of 17 coding exons spanning about 65.5 kb of genomic DNA [1].
  • Finally, as other proteins of the secretory pathway, hMDGA1 undergoes other post-translational modification consisting of N-glycosylation [2].
  • Moreover, our results reveal that hMDGA1 is localized specifically into membrane microdomains known as lipid rafts [2].
  • Our results demonstrate that human MDGA1 (hMDGA1) is localized in the membrane of eukaryotic cells [2].
  • The PDAI was validated against physician (MDGA) and patient (PGA) global assessments, and treatment was prescribed for the perianal disease [3].

Biological context of MDGA1

  • Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1 [4].
  • To test this hypothesis, we performed loss-of-function studies using RNA interference (RNAi) targeting different sequences of mouse MDGA1 [4].
  • RNAi transfections of deep layer neurons that do not express MDGA1 do not significantly affect their migration [4].

Anatomical context of MDGA1

  • We show in postnatal mice that MDGA1 is expressed by layer 2/3 neurons throughout the neocortex [4].

Associations of MDGA1 with chemical compounds


  1. Genomic organization of a novel glycosylphosphatidylinositol MAM gene expressed in human tissues and tumors. De Juan, C., Iniesta, P., González-Quevedo, R., Morán, A., Sánchez-Pernaute, A., Torres, A.J., Balibrea, J.L., Díaz-Rubio, E., Cruces, J., Benito, M. Oncogene (2002) [Pubmed]
  2. Characterization of MDGA1, a novel human glycosylphosphatidylinositol-anchored protein localized in lipid rafts. Díaz-López, A., Rivas, C., Iniesta, P., Morán, A., García-Aranda, C., Megías, D., Sánchez-Pernaute, A., Torres, A., Díaz-Rubio, E., Benito, M., De Juan, C. Exp. Cell Res. (2005) [Pubmed]
  3. Usual therapy improves perianal Crohn's disease as measured by a new disease activity index. McMaster IBD Study Group. Irvine, E.J. J. Clin. Gastroenterol. (1995) [Pubmed]
  4. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1. Takeuchi, A., O'Leary, D.D. J. Neurosci. (2006) [Pubmed]
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